Lynch MJ - Search Results

1

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.

Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. Sachs BD, et al. Among authors: lynch mj. J Cell Biol. 2007 Jun 18;177(6):1119-32. doi: 10.1083/jcb.200701040. J Cell Biol. 2007. PMID: 17576803 Free PMC article.

2

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

Li X, Huston E, Lynch MJ, Houslay MD, Baillie GS. Li X, et al. Among authors: lynch mj. Biochem J. 2006 Mar 1;394(Pt 2):427-35. doi: 10.1042/BJ20051560. Biochem J. 2006. PMID: 16356165 Free PMC article.

3

Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling.

Willoughby D, Baillie GS, Lynch MJ, Ciruela A, Houslay MD, Cooper DM. Willoughby D, et al. Among authors: lynch mj. J Biol Chem. 2007 Nov 23;282(47):34235-49. doi: 10.1074/jbc.M706765200. Epub 2007 Sep 13. J Biol Chem. 2007. PMID: 17855344 Free article.

4

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

Lynch MJ, Baillie GS, Houslay MD. Lynch MJ, et al. Biochem Soc Trans. 2007 Nov;35(Pt 5):938-41. doi: 10.1042/BST0350938. Biochem Soc Trans. 2007. PMID: 17956250 Review.

5

Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling.

Lynch MJ, Hill EV, Houslay MD. Lynch MJ, et al. Curr Top Dev Biol. 2006;75:225-59. doi: 10.1016/S0070-2153(06)75007-4. Curr Top Dev Biol. 2006. PMID: 16984814 Review.

6

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

Terrin A, Di Benedetto G, Pertegato V, Cheung YF, Baillie G, Lynch MJ, Elvassore N, Prinz A, Herberg FW, Houslay MD, Zaccolo M. Terrin A, et al. Among authors: lynch mj. J Cell Biol. 2006 Nov 6;175(3):441-51. doi: 10.1083/jcb.200605050. J Cell Biol. 2006. PMID: 17088426 Free PMC article.

7

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

McCahill A, Campbell L, McSorley T, Sood A, Lynch MJ, Li X, Yan C, Baillie GS, Houslay MD. McCahill A, et al. Among authors: lynch mj. Cell Signal. 2008 Nov;20(11):2071-83. doi: 10.1016/j.cellsig.2008.07.017. Epub 2008 Aug 5. Cell Signal. 2008. PMID: 18721873

8

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

Huston E, Lynch MJ, Mohamed A, Collins DM, Hill EV, MacLeod R, Krause E, Baillie GS, Houslay MD. Huston E, et al. Among authors: lynch mj. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12791-6. doi: 10.1073/pnas.0805167105. Epub 2008 Aug 26. Proc Natl Acad Sci U S A. 2008. PMID: 18728186 Free PMC article.

9

Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice.

Grønning LM, Baillie GS, Cederberg A, Lynch MJ, Houslay MD, Enerbäck S, Taskén K. Grønning LM, et al. Among authors: lynch mj. FEBS Lett. 2006 Jul 24;580(17):4126-30. doi: 10.1016/j.febslet.2006.06.058. Epub 2006 Jun 30. FEBS Lett. 2006. PMID: 16828089 Free article.

10

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD. Lynch MJ, et al. J Biol Chem. 2005 Sep 30;280(39):33178-89. doi: 10.1074/jbc.M414316200. Epub 2005 Jul 19. J Biol Chem. 2005. PMID: 16030021 Free article.

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