Carey PR - Search Results

1

Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes.

Kalp M, Sheri A, Buynak JD, Bethel CR, Bonomo RA, Carey PR. Kalp M, et al. Among authors: carey pr. J Biol Chem. 2007 Jul 27;282(30):21588-91. doi: 10.1074/jbc.C700080200. Epub 2007 Jun 8. J Biol Chem. 2007. PMID: 17561511 Free article.

2

High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.

Padayatti PS, Helfand MS, Totir MA, Carey MP, Carey PR, Bonomo RA, van den Akker F. Padayatti PS, et al. Among authors: carey pr, carey mp. J Biol Chem. 2005 Oct 14;280(41):34900-7. doi: 10.1074/jbc.M505333200. Epub 2005 Jul 29. J Biol Chem. 2005. PMID: 16055923 Free article.

3

Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.

Padayatti PS, Sheri A, Totir MA, Helfand MS, Carey MP, Anderson VE, Carey PR, Bethel CR, Bonomo RA, Buynak JD, van den Akker F. Padayatti PS, et al. Among authors: carey pr, carey mp. J Am Chem Soc. 2006 Oct 11;128(40):13235-42. doi: 10.1021/ja063715w. J Am Chem Soc. 2006. PMID: 17017804 Free PMC article.

4

Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.

Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR. Helfand MS, et al. Among authors: carey pr. Biochemistry. 2007 Jul 24;46(29):8689-99. doi: 10.1021/bi700581q. Epub 2007 Jun 27. Biochemistry. 2007. PMID: 17595114

5

Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.

Totir MA, Helfand MS, Carey MP, Sheri A, Buynak JD, Bonomo RA, Carey PR. Totir MA, et al. Among authors: carey pr, carey mp. Biochemistry. 2007 Aug 7;46(31):8980-7. doi: 10.1021/bi7006146. Epub 2007 Jul 13. Biochemistry. 2007. PMID: 17630699 Free PMC article.

6

Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.

Totir MA, Cha J, Ishiwata A, Wang B, Sheri A, Anderson VE, Buynak J, Mobashery S, Carey PR. Totir MA, et al. Among authors: carey pr. Biochemistry. 2008 Apr 1;47(13):4094-101. doi: 10.1021/bi702348w. Epub 2008 Mar 7. Biochemistry. 2008. PMID: 18324783

7

Carbapenems and SHV-1 beta-lactamase form different acyl-enzyme populations in crystals and solution.

Kalp M, Carey PR. Kalp M, et al. Among authors: carey pr. Biochemistry. 2008 Nov 11;47(45):11830-7. doi: 10.1021/bi800833u. Epub 2008 Oct 16. Biochemistry. 2008. PMID: 18922024 Free PMC article.

8

Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence.

Kalp M, Totir MA, Buynak JD, Carey PR. Kalp M, et al. Among authors: carey pr. J Am Chem Soc. 2009 Feb 18;131(6):2338-47. doi: 10.1021/ja808311s. J Am Chem Soc. 2009. PMID: 19161282 Free PMC article.

9

Why the extended-spectrum beta-lactamases SHV-2 and SHV-5 are "hypersusceptible" to mechanism-based inhibitors.

Kalp M, Bethel CR, Bonomo RA, Carey PR. Kalp M, et al. Among authors: carey pr. Biochemistry. 2009 Oct 20;48(41):9912-20. doi: 10.1021/bi9012098. Biochemistry. 2009. PMID: 19736945 Free PMC article.

10

Role of E166 in the imine to enamine tautomerization of the clinical beta-lactamase inhibitor sulbactam.

Kalp M, Buynak JD, Carey PR. Kalp M, et al. Among authors: carey pr. Biochemistry. 2009 Nov 3;48(43):10196-8. doi: 10.1021/bi901416t. Biochemistry. 2009. PMID: 19791797 Free PMC article.

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