Thomas CJ - Search Results

1

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

Tikhonova IG, Sum CS, Neumann S, Thomas CJ, Raaka BM, Costanzi S, Gershengorn MC. Tikhonova IG, et al. Among authors: thomas cj. J Med Chem. 2007 Jun 28;50(13):2981-9. doi: 10.1021/jm0614782. Epub 2007 Jun 7. J Med Chem. 2007. PMID: 17552505 Free PMC article.

2

1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.

Jiang JK, Thomas CJ, Neumann S, Lu X, Rice KC, Gershengorn MC. Jiang JK, et al. Among authors: thomas cj. Bioorg Med Chem Lett. 2005 Feb 1;15(3):733-6. doi: 10.1016/j.bmcl.2004.11.017. Bioorg Med Chem Lett. 2005. PMID: 15664847

3

Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.

Besada P, Mamedova L, Thomas CJ, Costanzi S, Jacobson KA. Besada P, et al. Among authors: thomas cj. Org Biomol Chem. 2005 May 21;3(10):2016-25. doi: 10.1039/b416349d. Epub 2005 Apr 21. Org Biomol Chem. 2005. PMID: 15889186 Free PMC article.

4

"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Lu C, Thomas CJ, Jacobson KA. Perreira M, et al. Among authors: thomas cj. J Med Chem. 2005 Jul 28;48(15):4910-8. doi: 10.1021/jm050221l. J Med Chem. 2005. PMID: 16033270 Free PMC article.

5

Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.

Perreira M, Kim EJ, Thomas CJ, Hanover JA. Perreira M, et al. Among authors: thomas cj. Bioorg Med Chem. 2006 Feb 1;14(3):837-46. doi: 10.1016/j.bmc.2005.09.013. Epub 2005 Oct 7. Bioorg Med Chem. 2006. PMID: 16214344

6

A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

Jäschke H, Neumann S, Moore S, Thomas CJ, Colson AO, Costanzi S, Kleinau G, Jiang JK, Paschke R, Raaka BM, Krause G, Gershengorn MC. Jäschke H, et al. Among authors: thomas cj. J Biol Chem. 2006 Apr 14;281(15):9841-4. doi: 10.1074/jbc.C600014200. Epub 2006 Feb 16. J Biol Chem. 2006. PMID: 16488885 Free article.

7

A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator.

Hu J, Jiang J, Costanzi S, Thomas C, Yang W, Feyen JHM, Jacobson KA, Spiegel AM. Hu J, et al. J Biol Chem. 2006 Jul 28;281(30):21558-21565. doi: 10.1074/jbc.M603682200. Epub 2006 May 30. J Biol Chem. 2006. PMID: 16735501 Free article.

8

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC. Moore S, et al. Among authors: thomas cj. J Med Chem. 2006 Jun 29;49(13):3888-96. doi: 10.1021/jm060247s. J Med Chem. 2006. PMID: 16789744 Free PMC article.

9

Fluorinated natural products with clinical significance.

Thomas CJ. Thomas CJ. Curr Top Med Chem. 2006;6(14):1529-43. doi: 10.2174/156802606777951109. Curr Top Med Chem. 2006. PMID: 16918466 Review.

10

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor.

Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Titus S, et al. Among authors: thomas cj. J Biomol Screen. 2008 Feb;13(2):120-7. doi: 10.1177/1087057107313786. Epub 2008 Jan 23. J Biomol Screen. 2008. PMID: 18216391 Free PMC article.

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