Langley BC - Search Results

1

Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.

Kozikowski AP, Chen Y, Gaysin A, Chen B, D'Annibale MA, Suto CM, Langley BC. Kozikowski AP, et al. Among authors: langley bc. J Med Chem. 2007 Jun 28;50(13):3054-61. doi: 10.1021/jm070178x. Epub 2007 Jun 1. J Med Chem. 2007. PMID: 17539623

2

Studies of benzamide- and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: identification of some HDAC3-selective inhibitors.

Chen Y, He R, Chen Y, D'Annibale MA, Langley B, Kozikowski AP. Chen Y, et al. ChemMedChem. 2009 May;4(5):842-52. doi: 10.1002/cmdc.200800461. ChemMedChem. 2009. PMID: 19350613

3

Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress.

Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Kozikowski AP, et al. ChemMedChem. 2009 Jul;4(7):1095-105. doi: 10.1002/cmdc.200900045. ChemMedChem. 2009. PMID: 19396896 Free PMC article.

4

Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups.

Butler KV, He R, McLaughlin K, Vistoli G, Langley B, Kozikowski AP. Butler KV, et al. ChemMedChem. 2009 Aug;4(8):1292-301. doi: 10.1002/cmdc.200900088. ChemMedChem. 2009. PMID: 19551801

5

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6. doi: 10.1021/ja102758v. J Am Chem Soc. 2010. PMID: 20614936 Free PMC article.

6

Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.

Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. Segretti MC, et al. ACS Med Chem Lett. 2015 Oct 5;6(11):1156-61. doi: 10.1021/acsmedchemlett.5b00303. eCollection 2015 Nov 12. ACS Med Chem Lett. 2015. PMID: 26617971 Free PMC article.

7

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.

Shen S, Picci C, Ustinova K, Benoy V, Kutil Z, Zhang G, Tavares MT, Pavlíček J, Zimprich CA, Robers MB, Van Den Bosch L, Bařinka C, Langley B, Kozikowski AP. Shen S, et al. J Med Chem. 2021 Apr 22;64(8):4810-4840. doi: 10.1021/acs.jmedchem.0c02210. Epub 2021 Apr 8. J Med Chem. 2021. PMID: 33830764

8

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.

Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Langley B, et al. J Neurosci. 2008 Jan 2;28(1):163-76. doi: 10.1523/JNEUROSCI.3200-07.2008. J Neurosci. 2008. PMID: 18171934 Free PMC article.

9

HDAC6 is a target for protection and regeneration following injury in the nervous system.

Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B. Rivieccio MA, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. doi: 10.1073/pnas.0907935106. Epub 2009 Nov 2. Proc Natl Acad Sci U S A. 2009. PMID: 19884510 Free PMC article.

10

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Sleiman SF, et al. Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345. Expert Opin Investig Drugs. 2009. PMID: 19388875 Free PMC article. Review.

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