Kozikowski AP - Search Results

1

Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.

Kozikowski AP, Chen Y, Gaysin A, Chen B, D'Annibale MA, Suto CM, Langley BC. Kozikowski AP, et al. J Med Chem. 2007 Jun 28;50(13):3054-61. doi: 10.1021/jm070178x. Epub 2007 Jun 1. J Med Chem. 2007. PMID: 17539623

2

Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors.

Chen B, Petukhov PA, Jung M, Velena A, Eliseeva E, Dritschilo A, Kozikowski AP. Chen B, et al. Among authors: kozikowski ap. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1389-92. doi: 10.1016/j.bmcl.2005.01.006. Bioorg Med Chem Lett. 2005. PMID: 15713393

3

Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth.

Kozikowski AP, Chen Y, Gaysin AM, Savoy DN, Billadeau DD, Kim KH. Kozikowski AP, et al. ChemMedChem. 2008 Mar;3(3):487-501. doi: 10.1002/cmdc.200700314. ChemMedChem. 2008. PMID: 18181121 Free PMC article.

4

A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.

Chen Y, Lopez-Sanchez M, Savoy DN, Billadeau DD, Dow GS, Kozikowski AP. Chen Y, et al. Among authors: kozikowski ap. J Med Chem. 2008 Jun 26;51(12):3437-48. doi: 10.1021/jm701606b. J Med Chem. 2008. PMID: 18494463

5

Studies of benzamide- and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: identification of some HDAC3-selective inhibitors.

Chen Y, He R, Chen Y, D'Annibale MA, Langley B, Kozikowski AP. Chen Y, et al. Among authors: kozikowski ap. ChemMedChem. 2009 May;4(5):842-52. doi: 10.1002/cmdc.200800461. ChemMedChem. 2009. PMID: 19350613

6

Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress.

Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Kozikowski AP, et al. ChemMedChem. 2009 Jul;4(7):1095-105. doi: 10.1002/cmdc.200900045. ChemMedChem. 2009. PMID: 19396896 Free PMC article.

7

Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.

He R, Chen Y, Chen Y, Ougolkov AV, Zhang JS, Savoy DN, Billadeau DD, Kozikowski AP. He R, et al. Among authors: kozikowski ap. J Med Chem. 2010 Feb 11;53(3):1347-56. doi: 10.1021/jm901667k. J Med Chem. 2010. PMID: 20055418 Free PMC article.

8

Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups.

Butler KV, He R, McLaughlin K, Vistoli G, Langley B, Kozikowski AP. Butler KV, et al. Among authors: kozikowski ap. ChemMedChem. 2009 Aug;4(8):1292-301. doi: 10.1002/cmdc.200900088. ChemMedChem. 2009. PMID: 19551801

9

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Butler KV, et al. Among authors: kozikowski ap. J Am Chem Soc. 2010 Aug 11;132(31):10842-6. doi: 10.1021/ja102758v. J Am Chem Soc. 2010. PMID: 20614936 Free PMC article.

10

Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.

Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. Segretti MC, et al. Among authors: kozikowski ap. ACS Med Chem Lett. 2015 Oct 5;6(11):1156-61. doi: 10.1021/acsmedchemlett.5b00303. eCollection 2015 Nov 12. ACS Med Chem Lett. 2015. PMID: 26617971 Free PMC article.

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