Chen L - Search Results

1

An affinity-based fluorescence polarization assay for protein tyrosine phosphatases.

Zhang S, Chen L, Kumar S, Wu L, Lawrence DS, Zhang ZY. Zhang S, et al. Among authors: chen l. Methods. 2007 Jul;42(3):261-7. doi: 10.1016/j.ymeth.2007.02.008. Methods. 2007. PMID: 17532513 Free PMC article.

2

Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy.

Zhang S, Chen L, Luo Y, Gunawan A, Lawrence DS, Zhang ZY. Zhang S, et al. Among authors: chen l. J Am Chem Soc. 2009 Sep 16;131(36):13072-9. doi: 10.1021/ja903733z. J Am Chem Soc. 2009. PMID: 19737019 Free PMC article.

3

Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.

Chen L, Zhou B, Zhang S, Wu L, Wang Y, Franzblau SG, Zhang ZY. Chen L, et al. ACS Med Chem Lett. 2010 Oct 14;1(7):355-359. doi: 10.1021/ml1001135. ACS Med Chem Lett. 2010. PMID: 21116447 Free PMC article.

4

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.

Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY. Yu ZH, et al. Among authors: chen l. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4238-42. doi: 10.1016/j.bmcl.2011.05.078. Epub 2011 May 30. Bioorg Med Chem Lett. 2011. PMID: 21669525 Free PMC article.

5

A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors.

Zhang S, Chen L, Lawrence DS, Zhang ZY. Zhang S, et al. Among authors: chen l. Methods Mol Biol. 2012;928:53-65. doi: 10.1007/978-1-62703-008-3_5. Methods Mol Biol. 2012. PMID: 22956133 Free PMC article.

6

A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.

Zhang S, Liu S, Tao R, Wei D, Chen L, Shen W, Yu ZH, Wang L, Jones DR, Dong XC, Zhang ZY. Zhang S, et al. Among authors: chen l. J Am Chem Soc. 2012 Oct 31;134(43):18116-24. doi: 10.1021/ja308212y. Epub 2012 Oct 17. J Am Chem Soc. 2012. PMID: 23075115 Free PMC article.

7

Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations.

Yu ZH, Xu J, Walls CD, Chen L, Zhang S, Zhang R, Wu L, Wang L, Liu S, Zhang ZY. Yu ZH, et al. Among authors: chen l. J Biol Chem. 2013 Apr 12;288(15):10472-82. doi: 10.1074/jbc.M113.450023. Epub 2013 Mar 1. J Biol Chem. 2013. PMID: 23457302 Free PMC article.

8

Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction.

Yakubov B, Chen L, Belkin AM, Zhang S, Chelladurai B, Zhang ZY, Matei D. Yakubov B, et al. Among authors: chen l. PLoS One. 2014 Feb 20;9(2):e89285. doi: 10.1371/journal.pone.0089285. eCollection 2014. PLoS One. 2014. PMID: 24586660 Free PMC article.

9

Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.

Yu ZH, Zhang RY, Walls CD, Chen L, Zhang S, Wu L, Liu S, Zhang ZY. Yu ZH, et al. Among authors: chen l. Biochemistry. 2014 Jul 1;53(25):4136-51. doi: 10.1021/bi5002695. Epub 2014 Jun 17. Biochemistry. 2014. PMID: 24935154 Free PMC article.

10

Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system.

van Rensburg JJ, Fortney KR, Chen L, Krieger AJ, Lima BP, Wolfe AJ, Katz BP, Zhang ZY, Spinola SM. van Rensburg JJ, et al. Among authors: chen l. Antimicrob Agents Chemother. 2015 Jul;59(7):3789-99. doi: 10.1128/AAC.00236-15. Epub 2015 Apr 13. Antimicrob Agents Chemother. 2015. PMID: 25870061 Free PMC article.

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