Islam I - Search Results

1

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO. Islam I, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. doi: 10.1016/j.bmcl.2007.04.071. Epub 2007 Apr 27. Bioorg Med Chem Lett. 2007. PMID: 17531483

2

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.

Islam I, Brown G, Bryant J, Hrvatin P, Kochanny MJ, Phillips GB, Yuan S, Adler M, Whitlow M, Lentz D, Polokoff MA, Wu J, Shen J, Walters J, Ho E, Subramanyam B, Zhu D, Feldman RI, Arnaiz DO. Islam I, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. doi: 10.1016/j.bmcl.2007.05.060. Epub 2007 May 23. Bioorg Med Chem Lett. 2007. PMID: 17544272

3

Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.

Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C, Sukovich D, Whitlow M, Chen D, Buckman BO. Islam I, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi: 10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. Bioorg Med Chem Lett. 2018. PMID: 30201291

4

3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).

Islam I, Bryant J, May K, Mohan R, Yuan S, Kent L, Morser J, Zhao L, Vergona R, White K, Adler M, Whitlow M, Buckman BO. Islam I, et al. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1349-54. doi: 10.1016/j.bmcl.2006.11.078. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17189688

5

Reversible, orally available ADP receptor (P2Y₁₂) antagonists Part I: Hit to lead process.

Islam I, Yuan S, Wei RG, Xu W, Morrissey M, Mohan R, Zheng D, DiMella A, Dunning L, Snider M, Subramanyam B, Tseng JL, Bryant JA, Buckman BO. Islam I, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1459-1463. doi: 10.1016/j.bmcl.2018.03.090. Epub 2018 Mar 31. Bioorg Med Chem Lett. 2018. PMID: 29628327

6

Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B.

Adler M, Bryant J, Buckman B, Islam I, Larsen B, Finster S, Kent L, May K, Mohan R, Yuan S, Whitlow M. Adler M, et al. Among authors: islam i. Biochemistry. 2005 Jul 5;44(26):9339-47. doi: 10.1021/bi0501941. Biochemistry. 2005. PMID: 15982000

7

A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.

Wang YX, Zhao L, Nagashima M, Vincelette J, Sukovich D, Li W, Subramanyam B, Yuan S, Emayan K, Islam I, Hrvatin P, Bryant J, Light DR, Vergona R, Morser J, Buckman BO. Wang YX, et al. Among authors: islam i. Thromb Haemost. 2007 Jan;97(1):45-53. Thromb Haemost. 2007. PMID: 17200770

8

Structures of potent selective peptide mimetics bound to carboxypeptidase B.

Adler M, Buckman B, Bryant J, Chang Z, Chu K, Emayan K, Hrvatin P, Islam I, Morser J, Sukovich D, West C, Yuan S, Whitlow M. Adler M, et al. Among authors: islam i. Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):149-57. doi: 10.1107/S0907444907057228. Epub 2008 Jan 16. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18219114

9

Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): in vitro effects on platelets.

Bryant J, Post JM, Alexander S, Wang YX, Kent L, Schirm S, Tseng JL, Subramanyam B, Buckman B, Islam I, Yuan S, Sullivan ME, Snider M, Morser J. Bryant J, et al. Among authors: islam i. Thromb Res. 2008;122(4):523-32. doi: 10.1016/j.thromres.2008.03.026. Epub 2008 May 20. Thromb Res. 2008. PMID: 18495218

10

A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.

Wang YX, Vincelette J, da Cunha V, Martin-McNulty B, Mallari C, Fitch RM, Alexander S, Islam I, Buckman BO, Yuan S, Post JM, Subramanyam B, Vergona R, Sullivan ME, Dole WP, Morser J, Bryant J. Wang YX, et al. Among authors: islam i. Thromb Haemost. 2007 May;97(5):847-55. Thromb Haemost. 2007. PMID: 17479197

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