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Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias.
Ouvrard-Pascaud A, Sainte-Marie Y, Bénitah JP, Perrier R, Soukaseum C, Nguyen Dinh Cat A, Royer A, Le Quang K, Charpentier F, Demolombe S, Mechta-Grigoriou F, Beggah AT, Maison-Blanche P, Oblin ME, Delcayre C, Fishman GI, Farman N, Escoubet B, Jaisser F. Ouvrard-Pascaud A, et al. Circulation. 2005 Jun 14;111(23):3025-33. doi: 10.1161/CIRCULATIONAHA.104.503706. Epub 2005 Jun 6. Circulation. 2005. PMID: 15939817 Free PMC article.
Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.
Sainte Marie Y, Toulon A, Paus R, Maubec E, Cherfa A, Grossin M, Descamps V, Clemessy M, Gasc JM, Peuchmaur M, Glick A, Farman N, Jaisser F. Sainte Marie Y, et al. Am J Pathol. 2007 Sep;171(3):846-60. doi: 10.2353/ajpath.2007.060991. Epub 2007 Aug 3. Am J Pathol. 2007. PMID: 17675581 Free PMC article.
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.
Loyer X, Gómez AM, Milliez P, Fernandez-Velasco M, Vangheluwe P, Vinet L, Charue D, Vaudin E, Zhang W, Sainte-Marie Y, Robidel E, Marty I, Mayer B, Jaisser F, Mercadier JJ, Richard S, Shah AM, Bénitah JP, Samuel JL, Heymes C. Loyer X, et al. Circulation. 2008 Jun 24;117(25):3187-98. doi: 10.1161/CIRCULATIONAHA.107.741702. Epub 2008 Jun 9. Circulation. 2008. PMID: 18541744 Free article.
Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins.
Gómez AM, Rueda A, Sainte-Marie Y, Pereira L, Zissimopoulos S, Zhu X, Schaub R, Perrier E, Perrier R, Latouche C, Richard S, Picot MC, Jaisser F, Lai FA, Valdivia HH, Benitah JP. Gómez AM, et al. Circulation. 2009 Apr 28;119(16):2179-87. doi: 10.1161/CIRCULATIONAHA.108.805804. Epub 2009 Apr 13. Circulation. 2009. PMID: 19364981 Free article.
24 results