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Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.
Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa-Suetsugu K, Akasaka R, Nishino Y, Toyama M, Chen L, Liu ZJ, Wang BC, Yamamoto M, Terada T, Miyazawa A, Tanaka A, Sugano S, Shirouzu M, Nagayama K, Takenawa T, Yokoyama S. Shimada A, et al. Among authors: niwa h. Cell. 2007 May 18;129(4):761-72. doi: 10.1016/j.cell.2007.03.040. Cell. 2007. PMID: 17512409 Free article.
Crystal structures of the S6K1 kinase domain in complexes with inhibitors.
Niwa H, Mikuni J, Sasaki S, Tomabechi Y, Honda K, Ikeda M, Ohsawa N, Wakiyama M, Handa N, Shirouzu M, Honma T, Tanaka A, Yokoyama S. Niwa H, et al. J Struct Funct Genomics. 2014 Sep;15(3):153-64. doi: 10.1007/s10969-014-9188-8. Epub 2014 Jul 31. J Struct Funct Genomics. 2014. PMID: 25078151 Free PMC article.
Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Takemoto Y, Ito A, Niwa H, Okamura M, Fujiwara T, Hirano T, Handa N, Umehara T, Sonoda T, Ogawa K, Tariq M, Nishino N, Dan S, Kagechika H, Yamori T, Yokoyama S, Yoshida M. Takemoto Y, et al. Among authors: niwa h. J Med Chem. 2016 Apr 28;59(8):3650-60. doi: 10.1021/acs.jmedchem.5b01732. Epub 2016 Apr 18. J Med Chem. 2016. PMID: 27088648
Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles.
Koda Y, Sato S, Yamamoto H, Niwa H, Watanabe H, Watanabe C, Sato T, Nakamura K, Tanaka A, Shirouzu M, Honma T, Fukami T, Koyama H, Umehara T. Koda Y, et al. Among authors: niwa h. ACS Med Chem Lett. 2022 Apr 29;13(5):848-854. doi: 10.1021/acsmedchemlett.2c00120. eCollection 2022 May 12. ACS Med Chem Lett. 2022. PMID: 35586426 Free PMC article.
Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2.
Niwa H, Watanabe C, Sato S, Harada T, Watanabe H, Tabusa R, Fukasawa S, Shiobara A, Hashimoto T, Ohno O, Nakamura K, Tsuganezawa K, Tanaka A, Shirouzu M, Honma T, Matsuno K, Umehara T. Niwa H, et al. ACS Med Chem Lett. 2022 Aug 18;13(9):1485-1492. doi: 10.1021/acsmedchemlett.2c00294. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105323 Free PMC article.
984 results