Kehne JH - Search Results

1

The CRF1 receptor, a novel target for the treatment of depression, anxiety, and stress-related disorders.

Kehne JH. Kehne JH. CNS Neurol Disord Drug Targets. 2007 Jun;6(3):163-82. doi: 10.2174/187152707780619344. CNS Neurol Disord Drug Targets. 2007. PMID: 17511614 Review.

2

Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders.

Kehne J, De Lombaert S. Kehne J, et al. Curr Drug Targets CNS Neurol Disord. 2002 Oct;1(5):467-93. doi: 10.2174/1568007023339049. Curr Drug Targets CNS Neurol Disord. 2002. PMID: 12769601 Review.

3

Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models.

Kehne JH, Cain CK. Kehne JH, et al. Pharmacol Ther. 2010 Dec;128(3):460-87. doi: 10.1016/j.pharmthera.2010.08.011. Epub 2010 Sep 6. Pharmacol Ther. 2010. PMID: 20826181 Free PMC article. Review.

4

Depression.

Duman RS, Kehne JH. Duman RS, et al. Among authors: kehne jh. CNS Neurol Disord Drug Targets. 2007 Jun;6(3):161-2. doi: 10.2174/187152707780619317. CNS Neurol Disord Drug Targets. 2007. PMID: 17511613 No abstract available.

5

Depression.

Duman RS, Kehne JH. Duman RS, et al. Among authors: kehne jh. CNS Neurol Disord Drug Targets. 2007 Apr;6(2):85-6. doi: 10.2174/187152707780363249. CNS Neurol Disord Drug Targets. 2007. PMID: 17430146 No abstract available.

6

2-Arylpyrimidines: novel CRF-1 receptor antagonists.

Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Krause JE, Hutchison A, Horvath RF, Ge P, Kehne J, Hoffman D, Chandrasekhar J, Doller D, Hodgetts KJ. Yoon T, et al. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4486-90. doi: 10.1016/j.bmcl.2008.07.063. Epub 2008 Jul 18. Bioorg Med Chem Lett. 2008. PMID: 18672365

7

The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.

Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Chandrasekhar J, Horvath RF, Ge P, Kershaw MT, Krause JE, Kehne J, Hoffman D, Doller D, Hodgetts KJ. Yoon T, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):891-6. doi: 10.1016/j.bmcl.2007.12.050. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18180159

8

Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups.

Kehne JH, Coverdale S, McCloskey TC, Hoffman DC, Cassella JV. Kehne JH, et al. Neuropharmacology. 2000 Jun 8;39(8):1357-67. doi: 10.1016/s0028-3908(00)00043-5. Neuropharmacology. 2000. PMID: 10818252

9

D2 receptor partial agonists: treatment of CNS disorders of dopamine function.

Kehne JH, Andree TH, Heinrich JN. Kehne JH, et al. Curr Top Med Chem. 2008;8(12):1068-88. doi: 10.2174/156802608785161394. Curr Top Med Chem. 2008. PMID: 18691133 Review.

10

Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.

Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Hodgetts KJ, et al. Among authors: kehne jh. J Med Chem. 2011 Jun 23;54(12):4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. J Med Chem. 2011. PMID: 21618986

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