Rubinsztein DC - Search Results

1

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Among authors: rubinsztein dc. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.

2

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease.

Carmichael J, Chatellier J, Woolfson A, Milstein C, Fersht AR, Rubinsztein DC. Carmichael J, et al. Among authors: rubinsztein dc. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9701-5. doi: 10.1073/pnas.170280697. Proc Natl Acad Sci U S A. 2000. PMID: 10920207 Free PMC article.

3

The molecular biology of Huntington's disease.

Ho LW, Carmichael J, Swartz J, Wyttenbach A, Rankin J, Rubinsztein DC. Ho LW, et al. Among authors: rubinsztein dc. Psychol Med. 2001 Jan;31(1):3-14. doi: 10.1017/s0033291799002871. Psychol Med. 2001. PMID: 11200958 Review.

4

Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease.

Ho LW, Brown R, Maxwell M, Wyttenbach A, Rubinsztein DC. Ho LW, et al. Among authors: rubinsztein dc. J Med Genet. 2001 Jul;38(7):450-2. doi: 10.1136/jmg.38.7.450. J Med Genet. 2001. PMID: 11432963 Free PMC article.

5

Lessons from animal models of Huntington's disease.

Rubinsztein DC. Rubinsztein DC. Trends Genet. 2002 Apr;18(4):202-9. doi: 10.1016/s0168-9525(01)02625-7. Trends Genet. 2002. PMID: 11932021 Review.

6

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Ravikumar B, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2002 May 1;11(9):1107-17. doi: 10.1093/hmg/11.9.1107. Hum Mol Genet. 2002. PMID: 11978769

7

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation.

Carmichael J, Sugars KL, Bao YP, Rubinsztein DC. Carmichael J, et al. Among authors: rubinsztein dc. J Biol Chem. 2002 Sep 13;277(37):33791-8. doi: 10.1074/jbc.M204861200. Epub 2002 Jul 3. J Biol Chem. 2002. PMID: 12097329 Free article.

8

The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington's disease.

Carmichael J, Vacher C, Rubinsztein DC. Carmichael J, et al. Among authors: rubinsztein dc. Neurosci Lett. 2002 Sep 27;330(3):270-4. doi: 10.1016/s0304-3940(02)00770-x. Neurosci Lett. 2002. PMID: 12270644

9

How useful are animal models of human disease?

Rubinsztein DC. Rubinsztein DC. Semin Cell Dev Biol. 2003 Feb;14(1):1-2. doi: 10.1016/s1084-9521(02)00159-3. Semin Cell Dev Biol. 2003. PMID: 12524000 No abstract available.

10

Transcriptional abnormalities in Huntington disease.

Sugars KL, Rubinsztein DC. Sugars KL, et al. Among authors: rubinsztein dc. Trends Genet. 2003 May;19(5):233-8. doi: 10.1016/S0168-9525(03)00074-X. Trends Genet. 2003. PMID: 12711212 Review.

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