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101 results

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Page 1
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Richardson TI, Frank SA, Wang M, Clarke CA, Jones SA, Ying BP, Kohlman DT, Wallace OB, Shepherd TA, Dally RD, Palkowitz AD, Geiser AG, Bryant HU, Henck JW, Cohen IR, Rudmann DG, McCann DJ, Coutant DE, Oldham SW, Hummel CW, Fong KC, Hinklin R, Lewis G, Tian H, Dodge JA. Richardson TI, et al. Among authors: bryant hu. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3544-9. doi: 10.1016/j.bmcl.2007.04.044. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17482463
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA. Hummel CW, et al. Among authors: bryant hu. J Med Chem. 2005 Nov 3;48(22):6772-5. doi: 10.1021/jm050723z. J Med Chem. 2005. PMID: 16250633
A selective estrogen receptor modulator for the treatment of hot flushes.
Wallace OB, Lauwers KS, Dodge JA, May SA, Calvin JR, Hinklin R, Bryant HU, Shetler PK, Adrian MD, Geiser AG, Sato M, Burris TP. Wallace OB, et al. Among authors: bryant hu. J Med Chem. 2006 Feb 9;49(3):843-6. doi: 10.1021/jm0509795. J Med Chem. 2006. PMID: 16451049
A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.
Geiser AG, Hummel CW, Draper MW, Henck JW, Cohen IR, Rudmann DG, Donnelly KB, Adrian MD, Shepherd TA, Wallace OB, McCann DJ, Oldham SW, Bryant HU, Sato M, Dodge JA. Geiser AG, et al. Among authors: bryant hu. Endocrinology. 2005 Oct;146(10):4524-35. doi: 10.1210/en.2005-0024. Epub 2005 Jul 7. Endocrinology. 2005. PMID: 16002528
Benzothiophene and naphthalene derived constrained SERMs.
Wallace OB, Bryant HU, Shetler PK, Adrian MD, Geiser AG. Wallace OB, et al. Among authors: bryant hu. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5103-6. doi: 10.1016/j.bmcl.2004.07.072. Bioorg Med Chem Lett. 2004. PMID: 15380208
Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene: a novel, highly potent, selective estrogen receptor modulator.
Palkowitz AD, Glasebrook AL, Thrasher KJ, Hauser KL, Short LL, Phillips DL, Muehl BS, Sato M, Shetler PK, Cullinan GJ, Pell TR, Bryant HU. Palkowitz AD, et al. Among authors: bryant hu. J Med Chem. 1997 May 9;40(10):1407-16. doi: 10.1021/jm970167b. J Med Chem. 1997. PMID: 9154963
Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus.
Helvering LM, Adrian MD, Geiser AG, Estrem ST, Wei T, Huang S, Chen P, Dow ER, Calley JN, Dodge JA, Grese TA, Jones SA, Halladay DL, Miles RR, Onyia JE, Ma YL, Sato M, Bryant HU. Helvering LM, et al. Among authors: bryant hu. Biol Reprod. 2005 Apr;72(4):830-41. doi: 10.1095/biolreprod.104.034595. Epub 2004 Dec 1. Biol Reprod. 2005. PMID: 15576828
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