Lin R - Search Results

1

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation.

Hughes TV, Emanuel SL, Beck AK, Wetter SK, Connolly PJ, Karnachi P, Reuman M, Seraj J, Fuentes-Pesquera AR, Gruninger RH, Middleton SA, Lin R, Davis JM, Moffat DF. Hughes TV, et al. Among authors: lin r. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3266-70. doi: 10.1016/j.bmcl.2007.04.021. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17481894

2

3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Lin R, Lu Y, Wetter SK, Connolly PJ, Turchi IJ, Murray WV, Emanuel SL, Gruninger RH, Fuentes-Pesquera AR, Adams M, Pandey N, Moreno-Mazza S, Middleton SA, Jolliffe LK. Lin R, et al. Bioorg Med Chem Lett. 2005 May 2;15(9):2221-4. doi: 10.1016/j.bmcl.2005.03.024. Bioorg Med Chem Lett. 2005. PMID: 15837297

3

1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.

Lin R, Connolly PJ, Huang S, Wetter SK, Lu Y, Murray WV, Emanuel SL, Gruninger RH, Fuentes-Pesquera AR, Rugg CA, Middleton SA, Jolliffe LK. Lin R, et al. J Med Chem. 2005 Jun 30;48(13):4208-11. doi: 10.1021/jm050267e. J Med Chem. 2005. PMID: 15974571

4

Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.

Huang S, Connolly PJ, Lin R, Emanuel S, Middleton SA. Huang S, et al. Among authors: lin r. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. doi: 10.1016/j.bmcl.2006.04.071. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682186

5

Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.

Huang S, Lin R, Yu Y, Lu Y, Connolly PJ, Chiu G, Li S, Emanuel SL, Middleton SA. Huang S, et al. Among authors: lin r. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1243-5. doi: 10.1016/j.bmcl.2006.12.031. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17234412

6

Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

Lin R, Connolly PJ, Lu Y, Chiu G, Li S, Yu Y, Huang S, Li X, Emanuel SL, Middleton SA, Gruninger RH, Adams M, Fuentes-Pesquera AR, Greenberger LM. Lin R, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4297-302. doi: 10.1016/j.bmcl.2007.05.029. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17532631

7

Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.

Lin R, Chiu G, Yu Y, Connolly PJ, Li S, Lu Y, Adams M, Fuentes-Pesquera AR, Emanuel SL, Greenberger LM. Lin R, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4557-61. doi: 10.1016/j.bmcl.2007.05.092. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574416

8

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

Lin R, Johnson SG, Connolly PJ, Wetter SK, Binnun E, Hughes TV, Murray WV, Pandey NB, Moreno-Mazza SJ, Adams M, Fuentes-Pesquera AR, Middleton SA. Lin R, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2333-7. doi: 10.1016/j.bmcl.2009.02.067. Epub 2009 Feb 21. Bioorg Med Chem Lett. 2009. PMID: 19286381

9

The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases.

Emanuel S, Rugg CA, Gruninger RH, Lin R, Fuentes-Pesquera A, Connolly PJ, Wetter SK, Hollister B, Kruger WW, Napier C, Jolliffe L, Middleton SA. Emanuel S, et al. Among authors: lin r. Cancer Res. 2005 Oct 1;65(19):9038-46. doi: 10.1158/0008-5472.CAN-05-0882. Cancer Res. 2005. PMID: 16204078

10

Syntheses of isotope-labeled SGLT2 inhibitor canagliflozin (JNJ-28431754).

Lin R, Hoerr DC, Weaner LE, Salter R. Lin R, et al. J Labelled Comp Radiopharm. 2017 Nov;60(13):616-623. doi: 10.1002/jlcr.3542. Epub 2017 Sep 18. J Labelled Comp Radiopharm. 2017. PMID: 28833358

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