Morton MF - Search Results

1

Obestatin reduces food intake and suppresses body weight gain in rodents.

Lagaud GJ, Young A, Acena A, Morton MF, Barrett TD, Shankley NP. Lagaud GJ, et al. Among authors: morton mf. Biochem Biophys Res Commun. 2007 May 25;357(1):264-9. doi: 10.1016/j.bbrc.2007.03.138. Epub 2007 Mar 30. Biochem Biophys Res Commun. 2007. Retraction in: Biochem Biophys Res Commun. 2009 Oct 23;388(3):619. doi: 10.1016/j.bbrc.2009.08.034 PMID: 17418097 Retracted.

2

Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice.

Prendergast CE, Morton MF, Figueroa KW, Wu X, Shankley NP. Prendergast CE, et al. Among authors: morton mf. Br J Pharmacol. 2006 Apr;147(8):886-96. doi: 10.1038/sj.bjp.0706677. Br J Pharmacol. 2006. PMID: 16474416 Free PMC article.

3

3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: in vitro and in vivo pharmacological comparison with dexloxiglumide.

Morton MF, Barrett TD, Yan W, Freedman JM, Lagaud G, Prendergast CE, Moreno V, Pyati J, Figueroa K, Li L, Wu X, Rizzolio M, Breitenbucher JG, McClure K, Shankley NP. Morton MF, et al. J Pharmacol Exp Ther. 2007 Nov;323(2):562-9. doi: 10.1124/jpet.107.124578. Epub 2007 Aug 7. J Pharmacol Exp Ther. 2007. PMID: 17684117

4

JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability.

Morton MF, Barrett TD, Freedman J, Li L, Rizzolio MC, Prendergast CE, Wu X, Moreno V, Pyati J, Figueroa K, Cagnon L, Lagaud G, Ver Donck L, Ghoos E, Allison B, Rabinowitz MH, Shankley NP. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. doi: 10.1124/jpet.110.178483. Epub 2011 Apr 14. J Pharmacol Exp Ther. 2011. PMID: 21493750

5

The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat.

Barrett TD, Lagaud G, Wagaman P, Freedman JM, Yan W, Andries L, Rizzolio MC, Morton MF, Shankley NP. Barrett TD, et al. Among authors: morton mf. Br J Pharmacol. 2012 Jul;166(5):1684-93. doi: 10.1111/j.1476-5381.2012.01878.x. Br J Pharmacol. 2012. PMID: 22300007 Free PMC article.

6

Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.

Allison BD, Phuong VK, McAtee LC, Rosen M, Morton M, Prendergast C, Barrett T, Lagaud G, Freedman J, Li L, Wu X, Venkatesan H, Pippel M, Woods C, Rizzolio MC, Hack M, Hoey K, Deng X, King C, Shankley NP, Rabinowitz MH. Allison BD, et al. J Med Chem. 2006 Oct 19;49(21):6371-90. doi: 10.1021/jm060590x. J Med Chem. 2006. PMID: 17034143

7

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists.

Gomez L, Hack MD, McClure K, Sehon C, Huang L, Morton M, Li L, Barrett TD, Shankley N, Breitenbucher JG. Gomez L, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6493-8. doi: 10.1016/j.bmcl.2007.09.093. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933530

8

Molecular cloning, expression and pharmacological characterization of the canine cholecystokinin 1 receptor.

Morton MF, Pyati J, Dai H, Li L, Moreno V, Shankley NP. Morton MF, et al. Br J Pharmacol. 2005 Jun;145(3):374-84. doi: 10.1038/sj.bjp.0706196. Br J Pharmacol. 2005. PMID: 15765098 Free PMC article.

9

Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands.

Woods CR, Hack MD, Allison BD, Phuong VK, Rosen MD, Morton MF, Prendergast CE, Barrett TD, Shankley NP, Rabinowitz MH. Woods CR, et al. Among authors: morton mf. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6905-9. doi: 10.1016/j.bmcl.2007.09.087. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 18029172

10

Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.

Rosen MD, Hack MD, Allison BD, Phuong VK, Woods CR, Morton MF, Prendergast CE, Barrett TD, Schubert C, Li L, Wu X, Wu J, Freedman JM, Shankley NP, Rabinowitz MH. Rosen MD, et al. Among authors: morton mf. Bioorg Med Chem. 2008 Apr 1;16(7):3917-25. doi: 10.1016/j.bmc.2008.01.059. Epub 2008 Feb 5. Bioorg Med Chem. 2008. PMID: 18289861

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