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473 results

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Page 1
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Dai Y, Hartandi K, Ji Z, Ahmed AA, Albert DH, Bauch JL, Bouska JJ, Bousquet PF, Cunha GA, Glaser KB, Harris CM, Hickman D, Guo J, Li J, Marcotte PA, Marsh KC, Moskey MD, Martin RL, Olson AM, Osterling DJ, Pease LJ, Soni NB, Stewart KD, Stoll VS, Tapang P, Reuter DR, Davidsen SK, Michaelides MR. Dai Y, et al. Among authors: harris cm. J Med Chem. 2007 Apr 5;50(7):1584-97. doi: 10.1021/jm061280h. Epub 2007 Mar 8. J Med Chem. 2007. PMID: 17343372
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
Dinges J, Albert DH, Arnold LD, Ashworth KL, Akritopoulou-Zanze I, Bousquet PF, Bouska JJ, Cunha GA, Davidsen SK, Diaz GJ, Djuric SW, Gasiecki AF, Gintant GA, Gracias VJ, Harris CM, Houseman KA, Hutchins CW, Johnson EF, Li H, Marcotte PA, Martin RL, Michaelides MR, Nyein M, Sowin TJ, Su Z, Tapang PH, Xia Z, Zhang HQ. Dinges J, et al. Among authors: harris cm. J Med Chem. 2007 May 3;50(9):2011-29. doi: 10.1021/jm061223o. Epub 2007 Apr 11. J Med Chem. 2007. PMID: 17425296
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Ji Z, Ahmed AA, Albert DH, Bouska JJ, Bousquet PF, Cunha GA, Diaz G, Glaser KB, Guo J, Harris CM, Li J, Marcotte PA, Moskey MD, Oie T, Pease L, Soni NB, Stewart KD, Davidsen SK, Michaelides MR. Ji Z, et al. Among authors: harris cm. J Med Chem. 2008 Mar 13;51(5):1231-41. doi: 10.1021/jm701096v. Epub 2008 Feb 9. J Med Chem. 2008. PMID: 18260617
2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Argiriadi MA, Ericsson AM, Harris CM, Banach DL, Borhani DW, Calderwood DJ, Demers MD, Dimauro J, Dixon RW, Hardman J, Kwak S, Li B, Mankovich JA, Marcotte D, Mullen KD, Ni B, Pietras M, Sadhukhan R, Sousa S, Tomlinson MJ, Wang L, Xiang T, Talanian RV. Argiriadi MA, et al. Among authors: harris cm. Bioorg Med Chem Lett. 2010 Jan 1;20(1):330-3. doi: 10.1016/j.bmcl.2009.10.102. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19919896
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.
Harris CM, Ericsson AM, Argiriadi MA, Barberis C, Borhani DW, Burchat A, Calderwood DJ, Cunha GA, Dixon RW, Frank KE, Johnson EF, Kamens J, Kwak S, Li B, Mullen KD, Perron DC, Wang L, Wishart N, Wu X, Zhang X, Zmetra TR, Talanian RV. Harris CM, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):334-7. doi: 10.1016/j.bmcl.2009.10.103. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19926477
Thienopyrrole acetic acids as antagonists of the CRTH2 receptor.
Bonafoux D, Abibi A, Bettencourt B, Burchat A, Ericsson A, Harris CM, Kebede T, Morytko M, McPherson M, Wallace G, Wu X. Bonafoux D, et al. Among authors: harris cm. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1861-4. doi: 10.1016/j.bmcl.2011.01.008. Epub 2011 Jan 14. Bioorg Med Chem Lett. 2011. PMID: 21316222
Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK. Hobson AD, et al. Among authors: harris cm. J Med Chem. 2015 Dec 10;58(23):9154-70. doi: 10.1021/acs.jmedchem.5b00928. Epub 2015 Nov 23. J Med Chem. 2015. PMID: 26509640
Creation of a S1P Lyase bacterial surrogate for structure-based drug design.
Argiriadi MA, Banach D, Radziejewska E, Marchie S, DiMauro J, Dinges J, Dominguez E, Hutchins C, Judge RA, Queeney K, Wallace G, Harris CM. Argiriadi MA, et al. Among authors: harris cm. Bioorg Med Chem Lett. 2016 May 1;26(9):2293-6. doi: 10.1016/j.bmcl.2016.02.084. Epub 2016 Mar 3. Bioorg Med Chem Lett. 2016. PMID: 27013389
Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors.
Dinges J, Harris CM, Wallace GA, Argiriadi MA, Queeney KL, Perron DC, Dominguez E, Kebede T, Desino KE, Patel H, Vasudevan A. Dinges J, et al. Among authors: harris cm. Bioorg Med Chem Lett. 2016 May 1;26(9):2297-302. doi: 10.1016/j.bmcl.2016.03.043. Epub 2016 Mar 14. Bioorg Med Chem Lett. 2016. PMID: 27020302
473 results