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Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.
McConnell O, Bach A 2nd, Balibar C, Byrne N, Cai Y, Carter G, Chlenov M, Di L, Fan K, Goljer I, He Y, Herold D, Kagan M, Kerns E, Koehn F, Kraml C, Marathias V, Marquez B, McDonald L, Nogle L, Petucci C, Schlingmann G, Tawa G, Tischler M, Williamson RT, Sutherland A, Watts W, Young M, Zhang MY, Zhang Y, Zhou D, Ho D. McConnell O, et al. Among authors: kraml c. Chirality. 2007 Sep;19(9):658-82. doi: 10.1002/chir.20399. Chirality. 2007. PMID: 17390370 Review.
Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis.
Caggiano TJ, Brazzale A, Ho DM, Kraml CM, Trybulski E, Chadwick CC, Chippari S, Borges-Marcucci L, Eckert A, Keith JC, Kenney T, Harnish DC. Caggiano TJ, et al. Among authors: kraml cm. J Med Chem. 2007 Nov 1;50(22):5245-8. doi: 10.1021/jm701013k. Epub 2007 Sep 29. J Med Chem. 2007. PMID: 17902637
Thermal C1-C5 diradical cyclization of enediynes.
Vavilala C, Byrne N, Kraml CM, Ho DM, Pascal RA Jr. Vavilala C, et al. Among authors: kraml cm. J Am Chem Soc. 2008 Oct 15;130(41):13549-51. doi: 10.1021/ja803413f. Epub 2008 Sep 18. J Am Chem Soc. 2008. PMID: 18798628
Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
Hatzenbuhler NT, Evrard DA, Harrison BL, Huryn D, Inghrim J, Kraml C, Mattes JF, Mewshaw RE, Zhou D, Hornby G, Lin Q, Smith DL, Sullivan KM, Schechter LE, Beyer CE, Andree TH. Hatzenbuhler NT, et al. Among authors: kraml c. J Med Chem. 2006 Jul 27;49(15):4785-9. doi: 10.1021/jm060218h. J Med Chem. 2006. PMID: 16854086
A pentacene with a 144 degrees twist.
Lu J, Ho DM, Vogelaar NJ, Kraml CM, Pascal RA Jr. Lu J, et al. J Am Chem Soc. 2004 Sep 15;126(36):11168-9. doi: 10.1021/ja046576w. J Am Chem Soc. 2004. PMID: 15355095
25 results