Light DR - Search Results

1

Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase.

Liang AM, Claret E, Ouled-Diaf J, Jean A, Vogel D, Light DR, Jones SW, Guilford WJ, Parkinson JF, Snider RM. Liang AM, et al. Among authors: light dr. J Biomol Screen. 2007 Jun;12(4):536-45. doi: 10.1177/1087057107299873. Epub 2007 Mar 23. J Biomol Screen. 2007. PMID: 17384330

2

Obligate multivalent recognition of cell surface tomoregulin following selection from a multivalent phage antibody library.

Heitner T, Satozawa N, McLean K, Vogel D, Cobb RR, Liu B, Mahmoudi M, Finster S, Larsen B, Zhu Y, Zhou H, Müller-Tiemann B, Monteclaro F, Zhao XY, Light DR. Heitner T, et al. Among authors: light dr. J Biomol Screen. 2006 Dec;11(8):985-95. doi: 10.1177/1087057106293841. Epub 2006 Nov 7. J Biomol Screen. 2006. PMID: 17092910

3

Discovery of the factor Xa inhibitor, ZK 807834 (CI-1031).

Light DR, Guilford WJ. Light DR, et al. Curr Top Med Chem. 2001 Jun;1(2):121-36. doi: 10.2174/1568026013395498. Curr Top Med Chem. 2001. PMID: 11899248 Review.

4

Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa.

Liang AM, Light DR, Kochanny M, Rumennik G, Trinh L, Lentz D, Post J, Morser J, Snider M. Liang AM, et al. Among authors: light dr. Biochem Pharmacol. 2003 May 1;65(9):1407-18. doi: 10.1016/s0006-2952(03)00084-4. Biochem Pharmacol. 2003. PMID: 12732352

5

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.

Whitlow M, Arnaiz DO, Buckman BO, Davey DD, Griedel B, Guilford WJ, Koovakkat SK, Liang A, Mohan R, Phillips GB, Seto M, Shaw KJ, Xu W, Zhao Z, Light DR, Morrissey MM. Whitlow M, et al. Among authors: light dr. Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1395-404. doi: 10.1107/s0907444999007350. Acta Crystallogr D Biol Crystallogr. 1999. PMID: 10417407

6

Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors.

Guilford WJ, Shaw KJ, Dallas JL, Koovakkat S, Lee W, Liang A, Light DR, McCarrick MA, Whitlow M, Ye B, Morrissey MM. Guilford WJ, et al. Among authors: light dr. J Med Chem. 1999 Dec 30;42(26):5415-25. doi: 10.1021/jm990456v. J Med Chem. 1999. PMID: 10639283

7

(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.

Shaw KJ, Guilford WJ, Dallas JL, Koovakkaat SK, McCarrick MA, Liang A, Light DR, Morrissey MM. Shaw KJ, et al. Among authors: light dr. J Med Chem. 1998 Sep 10;41(19):3551-6. doi: 10.1021/jm980281+. J Med Chem. 1998. PMID: 9733479 No abstract available.

8

The interaction of thrombomodulin with Ca2+.

Light DR, Glaser CB, Betts M, Blasko E, Campbell E, Clarke JH, McCaman M, McLean K, Nagashima M, Parkinson JF, Rumennik G, Young T, Morser J. Light DR, et al. Eur J Biochem. 1999 Jun;262(2):522-33. doi: 10.1046/j.1432-1327.1999.00398.x. Eur J Biochem. 1999. PMID: 10336638 Free article.

9

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.

Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM. Phillips GB, et al. Among authors: light dr. J Med Chem. 1998 Sep 10;41(19):3557-62. doi: 10.1021/jm980280h. J Med Chem. 1998. PMID: 9733480 No abstract available.

10

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture.

Xuan JA, Schneider D, Toy P, Lin R, Newton A, Zhu Y, Finster S, Vogel D, Mintzer B, Dinter H, Light D, Parry R, Polokoff M, Whitlow M, Wu Q, Parry G. Xuan JA, et al. Cancer Res. 2006 Apr 1;66(7):3611-9. doi: 10.1158/0008-5472.CAN-05-2983. Cancer Res. 2006. PMID: 16585186

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