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Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation.
Lambert KC, Curran EM, Judy BM, Milligan GN, Lubahn DB, Estes DM. Lambert KC, et al. Among authors: estes dm. J Immunol. 2005 Nov 1;175(9):5716-23. doi: 10.4049/jimmunol.175.9.5716. J Immunol. 2005. PMID: 16237062
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