Workman P - Search Results

1

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation.

Hardcastle A, Tomlin P, Norris C, Richards J, Cordwell M, Boxall K, Rowlands M, Jones K, Collins I, McDonald E, Workman P, Aherne W. Hardcastle A, et al. Among authors: workman p. Mol Cancer Ther. 2007 Mar;6(3):1112-22. doi: 10.1158/1535-7163.MCT-06-0496. Mol Cancer Ther. 2007. PMID: 17363504

2

Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Hostein I, et al. Among authors: workman p. Cancer Res. 2001 May 15;61(10):4003-9. Cancer Res. 2001. PMID: 11358818

3

High-throughput screening for identification of small molecule inhibitors of histone acetyltransferases using scintillating microplates (FlashPlate).

Turlais F, Hardcastle A, Rowlands M, Newbatt Y, Bannister A, Kouzarides T, Workman P, Aherne GW. Turlais F, et al. Among authors: workman p. Anal Biochem. 2001 Nov 1;298(1):62-8. doi: 10.1006/abio.2001.5340. Anal Biochem. 2001. PMID: 11673896

4

HSP90 as a new therapeutic target for cancer therapy: the story unfolds.

Maloney A, Workman P. Maloney A, et al. Among authors: workman p. Expert Opin Biol Ther. 2002 Jan;2(1):3-24. doi: 10.1517/14712598.2.1.3. Expert Opin Biol Ther. 2002. PMID: 11772336 Review.

5

Assays for the identification and evaluation of histone acetyltransferase inhibitors.

Wynne Aherne G, Rowlands MG, Stimson L, Workman P. Wynne Aherne G, et al. Among authors: workman p. Methods. 2002 Mar;26(3):245-53. doi: 10.1016/S1046-2023(02)00028-2. Methods. 2002. PMID: 12054880

6

Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.

Smith V, Rowlands MG, Barrie E, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Clin Cancer Res. 2002 Jun;8(6):2002-9. Clin Cancer Res. 2002. PMID: 12060646

7

Finding the needle in the haystack: why high-throughput screening is good for your health.

Aherne GW, McDonald E, Workman P. Aherne GW, et al. Among authors: workman p. Breast Cancer Res. 2002;4(4):148-54. doi: 10.1186/bcr440. Epub 2002 Jun 10. Breast Cancer Res. 2002. PMID: 12100740 Free PMC article.

8

Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides.

Ross PJ, George M, Cunningham D, DiStefano F, Andreyev HJ, Workman P, Clarke PA. Ross PJ, et al. Among authors: workman p. Mol Cancer Ther. 2001 Nov;1(1):29-41. Mol Cancer Ther. 2001. PMID: 12467236

9

Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone.

Workman P. Workman P. Cancer Detect Prev. 2002;26(6):405-10. doi: 10.1016/s0361-090x(02)00126-5. Cancer Detect Prev. 2002. PMID: 12507224 Review.

10

Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics.

Workman P. Workman P. Mol Cancer Ther. 2003 Feb;2(2):131-8. Mol Cancer Ther. 2003. PMID: 12589030 Review. No abstract available.

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