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1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.
Henderson EA, Alber DG, Baxter RC, Bithell SK, Budworth J, Carter MC, Chubb A, Cockerill GS, Dowdell VC, Fraser IJ, Harris RA, Keegan SJ, Kelsey RD, Lumley JA, Stables JN, Weerasekera N, Wilson LJ, Powell KL. Henderson EA, et al. Among authors: powell kl. J Med Chem. 2007 Apr 5;50(7):1685-92. doi: 10.1021/jm060747l. Epub 2007 Mar 7. J Med Chem. 2007. PMID: 17341059
1,4-Benzodiazepines as inhibitors of respiratory syncytial virus.
Carter MC, Alber DG, Baxter RC, Bithell SK, Budworth J, Chubb A, Cockerill GS, Dowdell VC, Henderson EA, Keegan SJ, Kelsey RD, Lockyer MJ, Stables JN, Wilson LJ, Powell KL. Carter MC, et al. Among authors: powell kl. J Med Chem. 2006 Apr 6;49(7):2311-9. doi: 10.1021/jm051185t. J Med Chem. 2006. PMID: 16570927
RSV604, a novel inhibitor of respiratory syncytial virus replication.
Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL. Chapman J, et al. Among authors: powell kl. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. doi: 10.1128/AAC.00211-07. Epub 2007 Jun 18. Antimicrob Agents Chemother. 2007. PMID: 17576833 Free PMC article.
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Cockerill GS, et al. J Med Chem. 2021 Apr 8;64(7):3658-3676. doi: 10.1021/acs.jmedchem.0c01882. Epub 2021 Mar 17. J Med Chem. 2021. PMID: 33729773
A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein.
DeVincenzo J, Tait D, Efthimiou J, Mori J, Kim YI, Thomas E, Wilson L, Harland R, Mathews N, Cockerill S, Powell K, Littler E. DeVincenzo J, et al. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01884-19. doi: 10.1128/AAC.01884-19. Print 2020 Jan 27. Antimicrob Agents Chemother. 2020. PMID: 31712214 Free PMC article. Clinical Trial.
Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy.
Mellor KM, Varma U, Koutsifeli P, Daniels LJ, Benson VL, Annandale M, Li X, Nursalim Y, Janssens JV, Weeks KL, Powell KL, O'Brien TJ, Katare R, Ritchie RH, Bell JR, Gottlieb RA, Delbridge LMD. Mellor KM, et al. Among authors: powell kl. J Mol Cell Cardiol. 2024 Apr;189:83-89. doi: 10.1016/j.yjmcc.2024.02.009. Epub 2024 Mar 13. J Mol Cell Cardiol. 2024. PMID: 38484473 Free article.
142 results