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INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Vernachio JH, Bleiman B, Bryant KD, Chamberlain S, Hunley D, Hutchins J, Ames B, Gorovits E, Ganguly B, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters CR, Wang J, Williams K, Patti JM, Henson G, Madela K, Aljarah M, Gilles A, McGuigan C. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May;55(5):1843-51. doi: 10.1128/AAC.01335-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357300 Free PMC article.
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
McGuigan C, Madela K, Aljarah M, Gilles A, Brancale A, Zonta N, Chamberlain S, Vernachio J, Hutchins J, Hall A, Ames B, Gorovits E, Ganguly B, Kolykhalov A, Wang J, Muhammad J, Patti JM, Henson G. McGuigan C, et al. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4. doi: 10.1016/j.bmcl.2010.06.094. Epub 2010 Jun 20. Bioorg Med Chem Lett. 2010. PMID: 20637609
Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G. McGuigan C, et al. J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792. J Med Chem. 2010. PMID: 20527890
Ultrasound-guided regional anesthesia (UGRA) in the emergency department: a scoping review.
Mahmood SMJ, Bhana NB, Kong C, Theyyunni N, Schaeffer WJ, Kropf CW, Klekowski NT, Munzer BW, Rotter ZB, Hall AE, Porath JD, Peterson WJ, Tucker RV. Mahmood SMJ, et al. Among authors: hall ae. Pain Manag. 2024 Oct-Nov;14(10-11):571-578. doi: 10.1080/17581869.2024.2431474. Epub 2024 Nov 24. Pain Manag. 2024. PMID: 39580644 Review.
Chemical Trends of the Bulk and Surface Termination-Dependent Electronic Structure of Metal-Intercalated Transition Metal Dichalcogenides.
Edwards B, Deaconu DA, Murgatroyd PAE, Buchberger S, Antonelli T, Halliday D, Siemann GR, Zivanovic A, Trzaska L, Rajan A, Abarca Morales E, Mayoh DA, Hall AE, Belosludov RV, Watson MD, Kim TK, Biswas D, Lee TL, Polley CM, Carbone D, Leandersson M, Balakrishnan G, Bahramy MS, King PDC. Edwards B, et al. Among authors: hall ae. Chem Mater. 2024 Jul 23;36(15):7117-7126. doi: 10.1021/acs.chemmater.4c00824. eCollection 2024 Aug 13. Chem Mater. 2024. PMID: 39156710 Free PMC article.
137 results