Congreve M - Search Results

1

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Congreve M, Aharony D, Albert J, Callaghan O, Campbell J, Carr RA, Chessari G, Cowan S, Edwards PD, Frederickson M, McMenamin R, Murray CW, Patel S, Wallis N. Congreve M, et al. J Med Chem. 2007 Mar 22;50(6):1124-32. doi: 10.1021/jm061197u. Epub 2007 Feb 22. J Med Chem. 2007. PMID: 17315857

2

Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs.

Scicinski JJ, Congreve MS, Jamieson C, Ley SV, Newman ES, Vinader VM, Carr RA. Scicinski JJ, et al. Among authors: congreve ms. J Comb Chem. 2001 Jul-Aug;3(4):387-96. doi: 10.1021/cc0100114. J Comb Chem. 2001. PMID: 11442396

3

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.

van Montfort RL, Congreve M, Tisi D, Carr R, Jhoti H. van Montfort RL, et al. Among authors: congreve m. Nature. 2003 Jun 12;423(6941):773-7. doi: 10.1038/nature01681. Nature. 2003. PMID: 12802339

4

Detection of ligands from a dynamic combinatorial library by X-ray crystallography.

Congreve MS, Davis DJ, Devine L, Granata C, O'Reilly M, Wyatt PG, Jhoti H. Congreve MS, et al. Angew Chem Int Ed Engl. 2003 Sep 29;42(37):4479-82. doi: 10.1002/anie.200351951. Angew Chem Int Ed Engl. 2003. PMID: 14520743 No abstract available.

5

A 'rule of three' for fragment-based lead discovery?

Congreve M, Carr R, Murray C, Jhoti H. Congreve M, et al. Drug Discov Today. 2003 Oct 1;8(19):876-7. doi: 10.1016/s1359-6446(03)02831-9. Drug Discov Today. 2003. PMID: 14554012 No abstract available.

6

Fragment-based lead discovery.

Rees DC, Congreve M, Murray CW, Carr R. Rees DC, et al. Among authors: congreve m. Nat Rev Drug Discov. 2004 Aug;3(8):660-72. doi: 10.1038/nrd1467. Nat Rev Drug Discov. 2004. PMID: 15286733 Review. No abstract available.

7

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H. Gill AL, et al. Among authors: congreve ms. J Med Chem. 2005 Jan 27;48(2):414-26. doi: 10.1021/jm049575n. J Med Chem. 2005. PMID: 15658855

8

Structural biology and drug discovery.

Congreve M, Murray CW, Blundell TL. Congreve M, et al. Drug Discov Today. 2005 Jul 1;10(13):895-907. doi: 10.1016/S1359-6446(05)03484-7. Drug Discov Today. 2005. PMID: 15993809 Review.

9

Fragment-based lead discovery: leads by design.

Carr RA, Congreve M, Murray CW, Rees DC. Carr RA, et al. Among authors: congreve m. Drug Discov Today. 2005 Jul 15;10(14):987-92. doi: 10.1016/S1359-6446(05)03511-7. Drug Discov Today. 2005. PMID: 16023057 Review.

10

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Howard N, et al. Among authors: congreve m. J Med Chem. 2006 Feb 23;49(4):1346-55. doi: 10.1021/jm050850v. J Med Chem. 2006. PMID: 16480269

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