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Overexpression of ribonucleotide reductase in transfected human KB cells increases their resistance to hydroxyurea: M2 but not M1 is sufficient to increase resistance to hydroxyurea in transfected cells.
Zhou BS, Hsu NY, Pan BC, Doroshow JH, Yen Y. Zhou BS, et al. Among authors: yen y. Cancer Res. 1995 Mar 15;55(6):1328-33. Cancer Res. 1995. PMID: 7882331
It has been shown that a HU-resistant clone derived from stepwise exposure to HU overexpresses the M2 mRNA and the RR protein (Y. Yen et al., Cancer Res., 54: 3868-3691, 1994). In this study, we established stable clones by transfecting human KB cells with the cDNA …
It has been shown that a HU-resistant clone derived from stepwise exposure to HU overexpresses the M2 mRNA and the RR protein (Y. …
Ribonucleotide reductase inhibitors and future drug design.
Shao J, Zhou B, Chu B, Yen Y. Shao J, et al. Among authors: yen y. Curr Cancer Drug Targets. 2006 Aug;6(5):409-31. doi: 10.2174/156800906777723949. Curr Cancer Drug Targets. 2006. PMID: 16918309 Review.
1,685 results