Opgenorth T - Search Results

1

Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.

Zinker B, Mika A, Nguyen P, Wilcox D, Ohman L, von Geldern TW, Opgenorth T, Jacobson P. Zinker B, et al. Among authors: opgenorth t. Metabolism. 2007 Mar;56(3):380-7. doi: 10.1016/j.metabol.2006.10.021. Metabolism. 2007. PMID: 17292727

2

Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

Jacobson PB, von Geldern TW, Ohman L, Osterland M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Marsh K, Beno DW, Nga-Nguyen B, Kym PR, Link JT, Tu N, Edgerton DS, Cherrington A, Efendic S, Lane BC, Opgenorth TJ. Jacobson PB, et al. Among authors: opgenorth tj. J Pharmacol Exp Ther. 2005 Jul;314(1):191-200. doi: 10.1124/jpet.104.081257. Epub 2005 Mar 22. J Pharmacol Exp Ther. 2005. PMID: 15784656

3

Metabolic responses with endothelin antagonism in a model of insulin resistance.

Berthiaume N, Wessale JL, Opgenorth TJ, Zinker BA. Berthiaume N, et al. Metabolism. 2005 Jun;54(6):735-40. doi: 10.1016/j.metabol.2004.12.019. Metabolism. 2005. PMID: 15931607

4

Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.

Edgerton DS, Jacobson PB, Opgenorth TJ, Zinker B, Beno D, von Geldern T, Ohman L, Scott M, Neal D, Cherrington AD. Edgerton DS, et al. Among authors: opgenorth tj. Metabolism. 2006 Sep;55(9):1255-62. doi: 10.1016/j.metabol.2006.05.011. Metabolism. 2006. PMID: 16919547

5

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR. Zinker BA, et al. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. doi: 10.1073/pnas.142298199. Epub 2002 Aug 8. Proc Natl Acad Sci U S A. 2002. PMID: 12169659 Free PMC article.

6

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists.

Jae HS, Winn M, Dixon DB, Marsh KC, Nguyen B, Opgenorth TJ, von Geldern TW. Jae HS, et al. Among authors: opgenorth tj. J Med Chem. 1997 Sep 26;40(20):3217-27. doi: 10.1021/jm970101g. J Med Chem. 1997. PMID: 9379441

7

Delivery of RNAi reagents in murine models of obesity and diabetes.

Wilcox DM, Yang R, Morgan SJ, Nguyen PT, Voorbach MJ, Jung PM, Haasch DL, Lin E, Bush EN, Opgenorth TJ, Jacobson PB, Collins CA, Rondinone CM, Surowy T, Landschulz KT. Wilcox DM, et al. Among authors: opgenorth tj. J RNAi Gene Silencing. 2006 Nov 29;3(1):225-36. J RNAi Gene Silencing. 2006. PMID: 19771218 Free PMC article.

8

Atrial natriuretic peptide and glomerular hyperfiltration during onset of spontaneous diabetes mellitus.

Okwueze MI, Opgenorth TJ, von Geldern TW, Vari RC. Okwueze MI, et al. Among authors: opgenorth tj. Am J Physiol. 1994 Feb;266(2 Pt 2):R572-7. doi: 10.1152/ajpregu.1994.266.2.R572. Am J Physiol. 1994. PMID: 8141417

9

Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain.

Liu G, Kozmina NS, Winn M, von Geldern TW, Chiou WJ, Dixon DB, Nguyen B, Marsh KC, Opgenorth TJ. Liu G, et al. Among authors: opgenorth tj. J Med Chem. 1999 Sep 9;42(18):3679-89. doi: 10.1021/jm990171i. J Med Chem. 1999. PMID: 10479299

10

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists.

Jae HS, Winn M, von Geldern TW, Sorensen BK, Chiou WJ, Nguyen B, Marsh KC, Opgenorth TJ. Jae HS, et al. Among authors: opgenorth tj. J Med Chem. 2001 Nov 8;44(23):3978-84. doi: 10.1021/jm010237l. J Med Chem. 2001. PMID: 11689084

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