Chen Z - Search Results

1

Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.

Tong Y, Claiborne A, Stewart KD, Park C, Kovar P, Chen Z, Credo RB, Gu WZ, Gwaltney SL 2nd, Judge RA, Zhang H, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tong Y, et al. Among authors: chen z. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. doi: 10.1016/j.bmc.2007.01.012. Epub 2007 Jan 17. Bioorg Med Chem. 2007. PMID: 17287122

2

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H. Xiao Z, et al. Among authors: chen z. J Biol Chem. 2003 Jun 13;278(24):21767-73. doi: 10.1074/jbc.M300229200. Epub 2003 Apr 3. J Biol Chem. 2003. PMID: 12676925 Free article.

3

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Wang GT, Li G, Mantei RA, Chen Z, Kovar P, Gu W, Xiao Z, Zhang H, Sham HL, Sowin T, Rosenberg SH, Lin NH. Wang GT, et al. Among authors: chen z. J Med Chem. 2005 May 5;48(9):3118-21. doi: 10.1021/jm048989d. J Med Chem. 2005. PMID: 15857116

4

Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors.

Lin NH, Xia P, Kovar P, Park C, Chen Z, Zhang H, Rosenberg SH, Sham HL. Lin NH, et al. Among authors: chen z. Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. doi: 10.1016/j.bmcl.2005.09.064. Epub 2005 Oct 18. Bioorg Med Chem Lett. 2006. PMID: 16242328

5

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.

Li G, Hasvold LA, Tao ZF, Wang GT, Gwaltney SL 2nd, Patel J, Kovar P, Credo RB, Chen Z, Zhang H, Park C, Sham HL, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Among authors: chen z. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2293-8. doi: 10.1016/j.bmcl.2006.01.028. Epub 2006 Jan 30. Bioorg Med Chem Lett. 2006. PMID: 16446090

6

Kinase drug discovery by affinity selection/mass spectrometry (ASMS): application to DNA damage checkpoint kinase Chk1.

Comess KM, Trumbull JD, Park C, Chen Z, Judge RA, Voorbach MJ, Coen M, Gao L, Tang H, Kovar P, Cheng X, Schurdak ME, Zhang H, Sowin T, Burns DJ. Comess KM, et al. Among authors: chen z. J Biomol Screen. 2006 Oct;11(7):755-64. doi: 10.1177/1087057106289972. Epub 2006 Sep 6. J Biomol Screen. 2006. PMID: 16956998

7

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.

Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang JY, Sowin TJ, Rosenberg SH, Zhang H. Chen Z, et al. Int J Cancer. 2006 Dec 15;119(12):2784-94. doi: 10.1002/ijc.22198. Int J Cancer. 2006. PMID: 17019715

8

Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.

Tao ZF, Wang L, Stewart KD, Chen Z, Gu W, Bui MH, Merta P, Zhang H, Kovar P, Johnson E, Park C, Judge R, Rosenberg S, Sowin T, Lin NH. Tao ZF, et al. Among authors: chen z. J Med Chem. 2007 Apr 5;50(7):1514-27. doi: 10.1021/jm061247v. Epub 2007 Mar 13. J Med Chem. 2007. PMID: 17352464

9

1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: extended exploration on phenyl ring substitutions and preliminary ADME/PK studies.

Tong Y, Claiborne A, Pyzytulinska M, Tao ZF, Stewart KD, Kovar P, Chen Z, Credo RB, Guan R, Merta PJ, Zhang H, Bouska J, Everitt EA, Murry BP, Hickman D, Stratton TJ, Wu J, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tong Y, et al. Among authors: chen z. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3618-23. doi: 10.1016/j.bmcl.2007.04.055. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17490879

10

Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.

Tao ZF, Li G, Tong Y, Chen Z, Merta P, Kovar P, Zhang H, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tao ZF, et al. Among authors: chen z. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4308-15. doi: 10.1016/j.bmcl.2007.05.027. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17544271

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