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The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, Wang HS, Schultz Jel J, Molkentin JD, Liggett SB, Dorn GW 2nd, Kranias EG. Zhao W, et al. Among authors: waggoner jr. Circulation. 2006 Feb 21;113(7):995-1004. doi: 10.1161/CIRCULATIONAHA.105.583351. Epub 2006 Feb 13. Circulation. 2006. PMID: 16476846
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
Haghighi K, Kolokathis F, Gramolini AO, Waggoner JR, Pater L, Lynch RA, Fan GC, Tsiapras D, Parekh RR, Dorn GW 2nd, MacLennan DH, Kremastinos DT, Kranias EG. Haghighi K, et al. Among authors: waggoner jr. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1388-93. doi: 10.1073/pnas.0510519103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432188 Free PMC article.
The anti-apoptotic protein HAX-1 is a regulator of cardiac function.
Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A, Robia SL, Kranias EG. Zhao W, et al. Among authors: waggoner jr. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20776-81. doi: 10.1073/pnas.0906998106. Epub 2009 Nov 17. Proc Natl Acad Sci U S A. 2009. PMID: 19920172 Free PMC article.
40 results