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Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.
Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks IP, Tarlinton DM, Novak U, Heath JK, Dunn AR. Ernst M, et al. Among authors: alexander ws. J Exp Med. 2001 Jul 16;194(2):189-203. doi: 10.1084/jem.194.2.189. J Exp Med. 2001. PMID: 11457894 Free PMC article.
SOCS3 negatively regulates IL-6 signaling in vivo.
Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS. Croker BA, et al. Among authors: alexander ws. Nat Immunol. 2003 Jun;4(6):540-5. doi: 10.1038/ni931. Epub 2003 May 18. Nat Immunol. 2003. PMID: 12754505
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.
Emery B, Cate HS, Marriott M, Merson T, Binder MD, Snell C, Soo PY, Murray S, Croker B, Zhang JG, Alexander WS, Cooper H, Butzkueven H, Kilpatrick TJ. Emery B, et al. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7859-64. doi: 10.1073/pnas.0602574103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682639 Free PMC article.
1,035 results