Horrevoets AJ - Search Results

1

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.

Fledderus JO, van Thienen JV, Boon RA, Dekker RJ, Rohlena J, Volger OL, Bijnens AP, Daemen MJ, Kuiper J, van Berkel TJ, Pannekoek H, Horrevoets AJ. Fledderus JO, et al. Among authors: horrevoets aj. Blood. 2007 May 15;109(10):4249-57. doi: 10.1182/blood-2006-07-036020. Epub 2007 Jan 23. Blood. 2007. PMID: 17244683 Free article.

2

Key transcriptional regulators of the vasoprotective effects of shear stress.

Boon RA, Horrevoets AJ. Boon RA, et al. Among authors: horrevoets aj. Hamostaseologie. 2009 Jan;29(1):39-40, 41-3. Hamostaseologie. 2009. PMID: 19151844 Review.

3

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2).

Dekker RJ, van Soest S, Fontijn RD, Salamanca S, de Groot PG, VanBavel E, Pannekoek H, Horrevoets AJ. Dekker RJ, et al. Among authors: horrevoets aj. Blood. 2002 Sep 1;100(5):1689-98. doi: 10.1182/blood-2002-01-0046. Blood. 2002. PMID: 12176889 Free article.

4

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes.

Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, Seppen J, de Vries CJ, Biessen EA, van Berkel TJ, Pannekoek H, Horrevoets AJ. Dekker RJ, et al. Among authors: horrevoets aj. Am J Pathol. 2005 Aug;167(2):609-18. doi: 10.1016/S0002-9440(10)63002-7. Am J Pathol. 2005. PMID: 16049344 Free PMC article.

5

KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium.

Dekker RJ, Boon RA, Rondaij MG, Kragt A, Volger OL, Elderkamp YW, Meijers JC, Voorberg J, Pannekoek H, Horrevoets AJ. Dekker RJ, et al. Among authors: horrevoets aj. Blood. 2006 Jun 1;107(11):4354-63. doi: 10.1182/blood-2005-08-3465. Epub 2006 Feb 2. Blood. 2006. PMID: 16455954 Free article.

6

Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.

van Thienen JV, Fledderus JO, Dekker RJ, Rohlena J, van Ijzendoorn GA, Kootstra NA, Pannekoek H, Horrevoets AJ. van Thienen JV, et al. Among authors: horrevoets aj. Cardiovasc Res. 2006 Nov 1;72(2):231-40. doi: 10.1016/j.cardiores.2006.07.008. Epub 2006 Jul 12. Cardiovasc Res. 2006. PMID: 16945356

7

KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1.

Boon RA, Fledderus JO, Volger OL, van Wanrooij EJ, Pardali E, Weesie F, Kuiper J, Pannekoek H, ten Dijke P, Horrevoets AJ. Boon RA, et al. Among authors: horrevoets aj. Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):532-9. doi: 10.1161/01.ATV.0000256466.65450.ce. Epub 2006 Dec 28. Arterioscler Thromb Vasc Biol. 2007. PMID: 17194892

8

KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells.

Fledderus JO, Boon RA, Volger OL, Hurttila H, Ylä-Herttuala S, Pannekoek H, Levonen AL, Horrevoets AJ. Fledderus JO, et al. Among authors: horrevoets aj. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1339-46. doi: 10.1161/ATVBAHA.108.165811. Epub 2008 May 8. Arterioscler Thromb Vasc Biol. 2008. PMID: 18467642

9

KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium.

Boon RA, Leyen TA, Fontijn RD, Fledderus JO, Baggen JM, Volger OL, van Nieuw Amerongen GP, Horrevoets AJ. Boon RA, et al. Among authors: horrevoets aj. Blood. 2010 Mar 25;115(12):2533-42. doi: 10.1182/blood-2009-06-228726. Epub 2009 Dec 23. Blood. 2010. PMID: 20032497 Free article.

10

Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo.

Fontijn RD, Volger OL, van der Pouw-Kraan TC, Doddaballapur A, Leyen T, Baggen JM, Boon RA, Horrevoets AJ. Fontijn RD, et al. Among authors: horrevoets aj. PLoS One. 2015 Dec 30;10(12):e0145777. doi: 10.1371/journal.pone.0145777. eCollection 2015. PLoS One. 2015. PMID: 26717516 Free PMC article.

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