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Page 1
The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists.
Méndez-Andino JL, Colson AO, Meyers KM, Mitchell MC, Hodge K, Howard JM, Kim N, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Suchanek P, Reizes O, Hu XE, Wos JA. Méndez-Andino JL, et al. Among authors: wos ja. Bioorg Med Chem. 2007 Mar 1;15(5):2092-105. doi: 10.1016/j.bmc.2006.12.028. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17236777
Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents.
Warshakoon NC, Sheville J, Bhatt RT, Ji W, Mendez-Andino JL, Meyers KM, Kim N, Wos JA, Mitchell C, Paris JL, Pinney BB, Reizes O, Hu XE. Warshakoon NC, et al. Among authors: wos ja. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5207-11. doi: 10.1016/j.bmcl.2006.07.006. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870427
Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG.
Meyers KM, Méndez-Andino JL, Colson AO, Warshakoon NC, Wos JA, Mitchell MC, Hodge KM, Howard JM, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Reizes O, Hu XE. Meyers KM, et al. Among authors: wos ja. Bioorg Med Chem Lett. 2007 Feb 1;17(3):819-22. doi: 10.1016/j.bmcl.2006.10.052. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107796
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists.
Meyers KM, Méndez-Andino J, Colson AO, Hu XE, Wos JA, Mitchell MC, Hodge K, Howard J, Paris JL, Dowty ME, Obringer CM, Reizes O. Meyers KM, et al. Among authors: wos ja. Bioorg Med Chem Lett. 2007 Feb 1;17(3):657-61. doi: 10.1016/j.bmcl.2006.10.096. Epub 2006 Nov 6. Bioorg Med Chem Lett. 2007. PMID: 17174091
Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.
Tian X, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA. Tian X, et al. Among authors: wos ja. J Med Chem. 2008 Oct 9;51(19):6055-66. doi: 10.1021/jm800525p. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771254
29 results