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Page 1
The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists.
Méndez-Andino JL, Colson AO, Meyers KM, Mitchell MC, Hodge K, Howard JM, Kim N, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Suchanek P, Reizes O, Hu XE, Wos JA. Méndez-Andino JL, et al. Among authors: reizes o. Bioorg Med Chem. 2007 Mar 1;15(5):2092-105. doi: 10.1016/j.bmc.2006.12.028. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17236777
Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents.
Warshakoon NC, Sheville J, Bhatt RT, Ji W, Mendez-Andino JL, Meyers KM, Kim N, Wos JA, Mitchell C, Paris JL, Pinney BB, Reizes O, Hu XE. Warshakoon NC, et al. Among authors: reizes o. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5207-11. doi: 10.1016/j.bmcl.2006.07.006. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870427
Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG.
Meyers KM, Méndez-Andino JL, Colson AO, Warshakoon NC, Wos JA, Mitchell MC, Hodge KM, Howard JM, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Reizes O, Hu XE. Meyers KM, et al. Among authors: reizes o. Bioorg Med Chem Lett. 2007 Feb 1;17(3):819-22. doi: 10.1016/j.bmcl.2006.10.052. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107796
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists.
Meyers KM, Méndez-Andino J, Colson AO, Hu XE, Wos JA, Mitchell MC, Hodge K, Howard J, Paris JL, Dowty ME, Obringer CM, Reizes O. Meyers KM, et al. Among authors: reizes o. Bioorg Med Chem Lett. 2007 Feb 1;17(3):657-61. doi: 10.1016/j.bmcl.2006.10.096. Epub 2006 Nov 6. Bioorg Med Chem Lett. 2007. PMID: 17174091
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.
Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschöp J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. Among authors: reizes o. Diabetes. 2008 Nov;57(11):2977-91. doi: 10.2337/db08-0161. Epub 2008 Aug 20. Diabetes. 2008. PMID: 18716045 Free PMC article.
Diet-induced obese mice are leptin insufficient after weight reduction.
Shi H, Akunuru S, Bierman JC, Hodge KM, Mitchell MC, Foster MT, Seeley RJ, Reizes O. Shi H, et al. Among authors: reizes o. Obesity (Silver Spring). 2009 Sep;17(9):1702-9. doi: 10.1038/oby.2009.106. Epub 2009 Apr 16. Obesity (Silver Spring). 2009. PMID: 19373220 Free PMC article.
84 results