Chung NN - Search Results

1

Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.

Tóth G, Ioja E, Tömböly C, Ballet S, Tourwé D, Péter A, Martinek T, Chung NN, Schiller PW, Benyhe S, Borsodi A. Tóth G, et al. Among authors: chung nn. J Med Chem. 2007 Jan 25;50(2):328-33. doi: 10.1021/jm060721u. J Med Chem. 2007. PMID: 17228874

2

A new structural motif for mu-opioid antagonists.

Van den Eynde I, Laus G, Schiller PW, Kosson P, Chung NN, Lipkowski AW, Tourwé D. Van den Eynde I, et al. Among authors: chung nn. J Med Chem. 2005 May 19;48(10):3644-8. doi: 10.1021/jm0491795. J Med Chem. 2005. PMID: 15887972

3

Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.

Lu Y, Lum TK, Leow Augustine YW, Weltrowska G, Nguyen TM, Lemieux C, Chung NN, Schiller PW. Lu Y, et al. Among authors: chung nn. J Med Chem. 2006 Aug 24;49(17):5382-5. doi: 10.1021/jm060369k. J Med Chem. 2006. PMID: 16913729

4

Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

Fichna J, do-Rego JC, Chung NN, Lemieux C, Schiller PW, Poels J, Broeck JV, Costentin J, Janecka A. Fichna J, et al. Among authors: chung nn. J Med Chem. 2007 Feb 8;50(3):512-20. doi: 10.1021/jm060998u. J Med Chem. 2007. PMID: 17266203

5

Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.

Berezowska I, Chung NN, Lemieux C, Wilkes BC, Schiller PW. Berezowska I, et al. Among authors: chung nn. J Med Chem. 2007 Mar 22;50(6):1414-7. doi: 10.1021/jm061294n. Epub 2007 Feb 22. J Med Chem. 2007. PMID: 17315860 Free PMC article.

6

Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].

Ghosh A, Luo J, Liu C, Weltrowska G, Lemieux C, Chung NN, Lu Y, Schiller PW. Ghosh A, et al. Among authors: chung nn. J Med Chem. 2008 Sep 25;51(18):5866-70. doi: 10.1021/jm8004702. J Med Chem. 2008. PMID: 18800771 Free PMC article.

7

Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).

Berezowska I, Chung NN, Lemieux C, Wilkes BC, Schiller PW. Berezowska I, et al. Among authors: chung nn. J Med Chem. 2009 Nov 12;52(21):6941-5. doi: 10.1021/jm9004913. J Med Chem. 2009. PMID: 19827750 Free PMC article.

8

Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.

Touati-Jallabe Y, Bojnik E, Legrand B, Mauchauffée E, Chung NN, Schiller PW, Benyhe S, Averlant-Petit MC, Martinez J, Hernandez JF. Touati-Jallabe Y, et al. Among authors: chung nn. J Med Chem. 2013 Jul 25;56(14):5964-5973. doi: 10.1021/jm4008592. Epub 2013 Jul 12. J Med Chem. 2013. PMID: 23822516 Free PMC article.

9

Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.

Tourwé D, Mannekens E, Diem TN, Verheyden P, Jaspers H, Tóth G, Péter A, Kertész I, Török G, Chung NN, Schiller PW. Tourwé D, et al. Among authors: chung nn. J Med Chem. 1998 Dec 17;41(26):5167-76. doi: 10.1021/jm981011u. J Med Chem. 1998. PMID: 9857087

10

Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.

Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. Rew Y, et al. Among authors: chung nn. J Med Chem. 2002 Aug 15;45(17):3746-54. doi: 10.1021/jm020108k. J Med Chem. 2002. PMID: 12166947

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