Ghanem M - Search Results

1

Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.

Rinaldo-Matthis A, Wing C, Ghanem M, Deng H, Wu P, Gupta A, Tyler PC, Evans GB, Furneaux RH, Almo SC, Wang CC, Schramm VL. Rinaldo-Matthis A, et al. Among authors: ghanem m. Biochemistry. 2007 Jan 23;46(3):659-68. doi: 10.1021/bi061515r. Biochemistry. 2007. PMID: 17223688 Free PMC article.

2

Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition.

Taylor EA, Rinaldo-Matthis A, Li L, Ghanem M, Hazleton KZ, Cassera MB, Almo SC, Schramm VL. Taylor EA, et al. Among authors: ghanem m. Biochemistry. 2007 Oct 30;46(43):12405-15. doi: 10.1021/bi7010256. Epub 2007 Oct 6. Biochemistry. 2007. PMID: 17918964

3

Tryptophan-free human PNP reveals catalytic site interactions.

Ghanem M, Saen-oon S, Zhadin N, Wing C, Cahill SM, Schwartz SD, Callender R, Schramm VL. Ghanem M, et al. Biochemistry. 2008 Mar 11;47(10):3202-15. doi: 10.1021/bi702491d. Epub 2008 Feb 13. Biochemistry. 2008. PMID: 18269249

4

Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase.

Ghanem M, Li L, Wing C, Schramm VL. Ghanem M, et al. Biochemistry. 2008 Feb 26;47(8):2559-64. doi: 10.1021/bi702132e. Biochemistry. 2008. PMID: 18281956

Thermodynamic parameters obtained from the temperature dependence studies of the chemical step establish E:R-PNP to be catalytically more efficient than the parent enzyme and reveal differences in the entropic component of catalysis. The two companion manuscripts (Luo, M., …

Thermodynamic parameters obtained from the temperature dependence studies of the chemical step establish E:R-PNP to be catalytically more ef …

5

Second-sphere amino acids contribute to transition-state structure in bovine purine nucleoside phosphorylase.

Li L, Luo M, Ghanem M, Taylor EA, Schramm VL. Li L, et al. Among authors: ghanem m. Biochemistry. 2008 Feb 26;47(8):2577-83. doi: 10.1021/bi7021365. Biochemistry. 2008. PMID: 18281958

6

Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics.

Ghanem M, Zhadin N, Callender R, Schramm VL. Ghanem M, et al. Biochemistry. 2009 Apr 28;48(16):3658-68. doi: 10.1021/bi802339c. Biochemistry. 2009. PMID: 19191546 Free PMC article.

7

Ribocation transition state capture and rebound in human purine nucleoside phosphorylase.

Ghanem M, Murkin AS, Schramm VL. Ghanem M, et al. Chem Biol. 2009 Sep 25;16(9):971-9. doi: 10.1016/j.chembiol.2009.07.012. Chem Biol. 2009. PMID: 19778725 Free PMC article.

8

Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase.

Silva RG, Hirschi JS, Ghanem M, Murkin AS, Schramm VL. Silva RG, et al. Among authors: ghanem m. Biochemistry. 2011 Apr 5;50(13):2701-9. doi: 10.1021/bi200279s. Epub 2011 Mar 10. Biochemistry. 2011. PMID: 21348499 Free PMC article.

9

Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase.

Saen-Oon S, Ghanem M, Schramm VL, Schwartz SD. Saen-Oon S, et al. Among authors: ghanem m. Biophys J. 2008 May 15;94(10):4078-88. doi: 10.1529/biophysj.107.121913. Epub 2008 Jan 30. Biophys J. 2008. PMID: 18234834 Free PMC article.

10

Spectroscopic and kinetic properties of recombinant choline oxidase from Arthrobacter globiformis.

Ghanem M, Fan F, Francis K, Gadda G. Ghanem M, et al. Biochemistry. 2003 Dec 30;42(51):15179-88. doi: 10.1021/bi035435o. Biochemistry. 2003. PMID: 14690428

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