Venäläinen JI - Search Results

1

2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JA, Forsberg MM, Männistö PT, Wallén EA. Jarho EM, et al. Among authors: venalainen ji. Bioorg Med Chem. 2007 Mar 1;15(5):2024-31. doi: 10.1016/j.bmc.2006.12.036. Epub 2006 Dec 24. Bioorg Med Chem. 2007. PMID: 17215128

2

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Saario SM, Forsberg MM, Venäläinen JI, Paso HM, Männistö PT, Gynther J. Wallén EA, et al. Among authors: venalainen ji. Bioorg Med Chem. 2002 Jul;10(7):2199-206. doi: 10.1016/s0968-0896(02)00061-5. Bioorg Med Chem. 2002. PMID: 11983517

3

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.

Venäläinen JI, Juvonen RO, Forsberg MM, Garcia-Horsman A, Poso A, Wallen EA, Gynther J, Männistö PT. Venäläinen JI, et al. Biochem Pharmacol. 2002 Aug 1;64(3):463-71. doi: 10.1016/s0006-2952(02)01184-x. Biochem Pharmacol. 2002. PMID: 12147298

4

Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. Wallén EA, et al. Among authors: venalainen ji. J Med Chem. 2002 Sep 26;45(20):4581-4. doi: 10.1021/jm020966g. J Med Chem. 2002. PMID: 12238937

5

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Saarinen TJ, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. Wallén EA, et al. Among authors: venalainen ji. Bioorg Med Chem. 2003 Aug 15;11(17):3611-9. doi: 10.1016/s0968-0896(03)00363-8. Bioorg Med Chem. 2003. PMID: 12901906

6

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.

Wallén EA, Christiaans JA, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. Wallén EA, et al. Among authors: venalainen ji. J Med Chem. 2003 Oct 9;46(21):4543-51. doi: 10.1021/jm030811o. J Med Chem. 2003. PMID: 14521416

7

Evolutionary relationships of the prolyl oligopeptidase family enzymes.

Venäläinen JI, Juvonen RO, Männistö PT. Venäläinen JI, et al. Eur J Biochem. 2004 Jul;271(13):2705-15. doi: 10.1111/j.1432-1033.2004.04199.x. Eur J Biochem. 2004. PMID: 15206935 Free article.

8

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.

Venäläinen JI, Juvonen RO, Garcia-Horsman JA, Wallén EA, Christiaans JA, Jarho EM, Gynther J, Männistö PT. Venäläinen JI, et al. Biochem J. 2004 Sep 15;382(Pt 3):1003-8. doi: 10.1042/BJ20040992. Biochem J. 2004. PMID: 15217351 Free PMC article.

9

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Huuskonen J, Christiaans JA, Garcia-Horsman JA, Forsberg MM, Järvinen T, Gynther J, Männistö PT, Wallén EA. Jarho EM, et al. Among authors: venalainen ji. J Med Chem. 2004 Nov 4;47(23):5605-7. doi: 10.1021/jm049503w. J Med Chem. 2004. PMID: 15509157

10

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

Jarho EM, Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J, Poso A. Jarho EM, et al. Among authors: venalainen ji. J Med Chem. 2005 Jul 28;48(15):4772-82. doi: 10.1021/jm0500020. J Med Chem. 2005. PMID: 16033257

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