Männistö PT - Search Results

1

2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JA, Forsberg MM, Männistö PT, Wallén EA. Jarho EM, et al. Among authors: mannisto pt. Bioorg Med Chem. 2007 Mar 1;15(5):2024-31. doi: 10.1016/j.bmc.2006.12.036. Epub 2006 Dec 24. Bioorg Med Chem. 2007. PMID: 17215128

2

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.

Venäläinen JI, Juvonen RO, Garcia-Horsman JA, Wallén EA, Christiaans JA, Jarho EM, Gynther J, Männistö PT. Venäläinen JI, et al. Among authors: mannisto pt. Biochem J. 2004 Sep 15;382(Pt 3):1003-8. doi: 10.1042/BJ20040992. Biochem J. 2004. PMID: 15217351 Free PMC article.

3

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Huuskonen J, Christiaans JA, Garcia-Horsman JA, Forsberg MM, Järvinen T, Gynther J, Männistö PT, Wallén EA. Jarho EM, et al. Among authors: mannisto pt. J Med Chem. 2004 Nov 4;47(23):5605-7. doi: 10.1021/jm049503w. J Med Chem. 2004. PMID: 15509157

4

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

Jarho EM, Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J, Poso A. Jarho EM, et al. Among authors: mannisto pt. J Med Chem. 2005 Jul 28;48(15):4772-82. doi: 10.1021/jm0500020. J Med Chem. 2005. PMID: 16033257

5

Synthesis and characterization of the novel fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine.

Venäläinen JI, Wallén EA, Poso A, García-Horsman JA, Männistö PT. Venäläinen JI, et al. Among authors: mannisto pt. J Med Chem. 2005 Nov 17;48(23):7093-5. doi: 10.1021/jm0509187. J Med Chem. 2005. PMID: 16279765

6

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

Venäläinen JI, Garcia-Horsman JA, Forsberg MM, Jalkanen A, Wallén EA, Jarho EM, Christiaans JA, Gynther J, Männistö PT. Venäläinen JI, et al. Among authors: mannisto pt. Biochem Pharmacol. 2006 Feb 28;71(5):683-92. doi: 10.1016/j.bcp.2005.11.029. Epub 2006 Jan 6. Biochem Pharmacol. 2006. PMID: 16405869

7

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JA, Forsberg MM, Järvinen T, Männistö PT, Wallén EA. Jarho EM, et al. Among authors: mannisto pt. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5590-3. doi: 10.1016/j.bmcl.2006.08.029. Epub 2006 Aug 17. Bioorg Med Chem Lett. 2006. PMID: 16919454

8

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats.

Jalkanen AJ, Puttonen KA, Venäläinen JI, Sinervä V, Mannila A, Ruotsalainen S, Jarho EM, Wallén EA, Männistö PT. Jalkanen AJ, et al. Among authors: mannisto pt. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):132-8. doi: 10.1111/j.1742-7843.2006.00021.x. Basic Clin Pharmacol Toxicol. 2007. PMID: 17244263 Free article.

9

Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo.

Kallinen A, Todorov B, Kallionpää R, Bäck S, Sarparanta M, Raki M, García-Horsman JA, Bergström KA, Wallén EA, Männistö PT, Airaksinen AJ. Kallinen A, et al. Among authors: mannisto pt. Eur J Med Chem. 2014 May 22;79:436-45. doi: 10.1016/j.ejmech.2014.04.014. Epub 2014 Apr 12. Eur J Med Chem. 2014. PMID: 24763264

10

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Saario SM, Forsberg MM, Venäläinen JI, Paso HM, Männistö PT, Gynther J. Wallén EA, et al. Among authors: mannisto pt. Bioorg Med Chem. 2002 Jul;10(7):2199-206. doi: 10.1016/s0968-0896(02)00061-5. Bioorg Med Chem. 2002. PMID: 11983517

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