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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Hundhausen C, et al. Among authors: ludwig a. Blood. 2003 Aug 15;102(4):1186-95. doi: 10.1182/blood-2002-12-3775. Epub 2003 Apr 24. Blood. 2003. PMID: 12714508 Free article.
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A. Abel S, et al. Among authors: ludwig a. J Immunol. 2004 May 15;172(10):6362-72. doi: 10.4049/jimmunol.172.10.6362. J Immunol. 2004. PMID: 15128827
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S. Budagian V, et al. Among authors: ludwig a. J Biol Chem. 2004 Sep 24;279(39):40368-75. doi: 10.1074/jbc.M404125200. Epub 2004 Jun 23. J Biol Chem. 2004. Retraction in: J Biol Chem. 2011 Mar 18;286(11):9894. doi: 10.1074/jbc.a110.404125 PMID: 15215246 Free article. Retracted.
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.
Budagian V, Bulanova E, Orinska Z, Duitman E, Brandt K, Ludwig A, Hartmann D, Lemke G, Saftig P, Bulfone-Paus S. Budagian V, et al. Among authors: ludwig a. Mol Cell Biol. 2005 Nov;25(21):9324-39. doi: 10.1128/MCB.25.21.9324-9339.2005. Mol Cell Biol. 2005. Retraction in: Mol Cell Biol. 2011 Mar;31(6):1330. doi: 10.1128/MCB.05019-11 PMID: 16227584 Free PMC article. Retracted.
1,314 results