Li Y - Search Results

1

Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay.

Liu H, Gao ZB, Yao Z, Zheng S, Li Y, Zhu W, Tan X, Luo X, Shen J, Chen K, Hu GY, Jiang H. Liu H, et al. Among authors: li y. J Med Chem. 2007 Jan 11;50(1):83-93. doi: 10.1021/jm060414o. J Med Chem. 2007. PMID: 17201412

2

Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.

Li Y, Hu GY. Li Y, et al. Neurosci Lett. 2002 May 10;324(1):25-8. doi: 10.1016/s0304-3940(02)00167-2. Neurosci Lett. 2002. PMID: 11983286

3

Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons.

Li Y, Hu GY. Li Y, et al. Neurosci Lett. 2002 Aug 30;329(2):153-6. doi: 10.1016/s0304-3940(02)00620-1. Neurosci Lett. 2002. PMID: 12165400

4

Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing.

Liu H, Li Y, Song M, Tan X, Cheng F, Zheng S, Shen J, Luo X, Ji R, Yue J, Hu G, Jiang H, Chen K. Liu H, et al. Among authors: li y. Chem Biol. 2003 Nov;10(11):1103-13. doi: 10.1016/j.chembiol.2003.10.011. Chem Biol. 2003. PMID: 14652078

5

Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABA(A) receptor antagonist in rat brain.

Zhao XY, Wang Y, Li Y, Chen XQ, Yang HH, Yue JM, Hu GY. Zhao XY, et al. Among authors: li y. Neurosci Lett. 2003 Jan 30;337(1):33-6. doi: 10.1016/s0304-3940(02)01299-5. Neurosci Lett. 2003. PMID: 12524165

6

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation.

Chen L, Zhang Q, Qiu Y, Li Z, Chen Z, Jiang H, Li Y, Yang H. Chen L, et al. Among authors: li y, li z. Sci Rep. 2015 Oct 15;5:15079. doi: 10.1038/srep15079. Sci Rep. 2015. PMID: 26469389 Free PMC article.

7

Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating.

Ma Y, Luo Q, Fu J, Che Y, Guo F, Mei L, Zhang Q, Li Y, Yang H. Ma Y, et al. Among authors: li y. J Med Chem. 2020 Oct 8;63(19):10972-10983. doi: 10.1021/acs.jmedchem.0c00842. Epub 2020 Sep 16. J Med Chem. 2020. PMID: 32877186

8

Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel.

Chai H, Cheng X, Zhou B, Zhao L, Lin X, Huang D, Lu W, Lv H, Tang F, Zhang Q, Huang W, Li Y, Yang H. Chai H, et al. Among authors: li y. J Med Chem. 2019 Feb 14;62(3):1373-1384. doi: 10.1021/acs.jmedchem.8b01496. Epub 2019 Jan 16. J Med Chem. 2019. PMID: 30620187

9

Identification of new potent A₁ adenosine receptor antagonists using a multistage virtual screening approach.

Wei Y, Wang M, Li Y, Hong Z, Li D, Lin J. Wei Y, et al. Among authors: li d, li y. Eur J Med Chem. 2020 Feb 1;187:111936. doi: 10.1016/j.ejmech.2019.111936. Epub 2019 Dec 4. Eur J Med Chem. 2020. PMID: 31855793

10

Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer's disease.

Zhou LC, Liang YF, Huang Y, Yang GX, Zheng LL, Sun JM, Li Y, Zhu FL, Qian HW, Wang R, Ma L. Zhou LC, et al. Among authors: li y. Eur J Med Chem. 2021 Jul 5;219:113426. doi: 10.1016/j.ejmech.2021.113426. Epub 2021 Apr 3. Eur J Med Chem. 2021. PMID: 33848787

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