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Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins.
Kraiczy P, Hellwage J, Skerka C, Becker H, Kirschfink M, Simon MM, Brade V, Zipfel PF, Wallich R. Kraiczy P, et al. Among authors: simon mm. J Biol Chem. 2004 Jan 23;279(4):2421-9. doi: 10.1074/jbc.M308343200. Epub 2003 Nov 7. J Biol Chem. 2004. PMID: 14607842 Free article.
Borrelia burgdorferi complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to nondenatured structural determinants.
Rossmann E, Kitiratschky V, Hofmann H, Kraiczy P, Simon MM, Wallich R. Rossmann E, et al. Among authors: simon mm. Infect Immun. 2006 Dec;74(12):7024-8. doi: 10.1128/IAI.01028-06. Epub 2006 Sep 25. Infect Immun. 2006. PMID: 17000728 Free PMC article.
Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.
Siegel C, Schreiber J, Haupt K, Skerka C, Brade V, Simon MM, Stevenson B, Wallich R, Zipfel PF, Kraiczy P. Siegel C, et al. Among authors: simon mm. J Biol Chem. 2008 Dec 12;283(50):34855-63. doi: 10.1074/jbc.M805844200. Epub 2008 Sep 29. J Biol Chem. 2008. PMID: 18824548 Free PMC article.
Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H.
Kraiczy P, Hanssen-Hübner C, Kitiratschky V, Brenner C, Besier S, Brade V, Simon MM, Skerka C, Roversi P, Lea SM, Stevenson B, Wallich R, Zipfel PF. Kraiczy P, et al. Among authors: simon mm. Int J Med Microbiol. 2009 Apr;299(4):255-68. doi: 10.1016/j.ijmm.2008.09.002. Epub 2009 Jan 9. Int J Med Microbiol. 2009. PMID: 19138559
Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi.
Cordes FS, Kraiczy P, Roversi P, Skerka C, Kirschfink M, Simon MM, Brade V, Lowe ED, Zipfel P, Wallich R, Lea SM. Cordes FS, et al. Among authors: simon mm. Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):929-32. doi: 10.1107/S090744490400472X. Epub 2004 Apr 21. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 15103142
301 results