Hersh LB - Search Results

1

Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation.

Song ES, Cady C, Fried MG, Hersh LB. Song ES, et al. Among authors: hersh lb. Biochemistry. 2006 Dec 19;45(50):15085-91. doi: 10.1021/bi061298u. Biochemistry. 2006. PMID: 17154546 Free PMC article.

2

ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.

Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2004 Dec 24;279(52):54216-20. doi: 10.1074/jbc.M411177200. Epub 2004 Oct 19. J Biol Chem. 2004. PMID: 15494400 Free article.

3

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions.

Song ES, Daily A, Fried MG, Juliano MA, Juliano L, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2005 May 6;280(18):17701-6. doi: 10.1074/jbc.M501896200. Epub 2005 Mar 3. J Biol Chem. 2005. PMID: 15749695 Free article.

4

Insulysin: an allosteric enzyme as a target for Alzheimer's disease.

Song ES, Hersh LB. Song ES, et al. Among authors: hersh lb. J Mol Neurosci. 2005;25(3):201-6. doi: 10.1385/JMN:25:3:201. J Mol Neurosci. 2005. PMID: 15800373

5

Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral.

Shinall H, Song ES, Hersh LB. Shinall H, et al. Among authors: hersh lb. Biochemistry. 2005 Nov 22;44(46):15345-50. doi: 10.1021/bi050650l. Biochemistry. 2005. PMID: 16285738

6

A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties.

Song ES, Rodgers DW, Hersh LB. Song ES, et al. Among authors: hersh lb. PLoS One. 2010 Mar 16;5(3):e9719. doi: 10.1371/journal.pone.0009719. PLoS One. 2010. PMID: 20300529 Free PMC article.

7

Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism.

Song ES, Rodgers DW, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2011 Apr 22;286(16):13852-8. doi: 10.1074/jbc.M110.191668. Epub 2011 Feb 22. J Biol Chem. 2011. PMID: 21343292 Free PMC article.

8

Identification of the allosteric regulatory site of insulysin.

Noinaj N, Bhasin SK, Song ES, Scoggin KE, Juliano MA, Juliano L, Hersh LB, Rodgers DW. Noinaj N, et al. Among authors: hersh lb. PLoS One. 2011;6(6):e20864. doi: 10.1371/journal.pone.0020864. Epub 2011 Jun 24. PLoS One. 2011. PMID: 21731629 Free PMC article.

9

Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates.

Song ES, Mukherjee A, Juliano MA, Pyrek JS, Goodman JP Jr, Juliano L, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2001 Jan 12;276(2):1152-5. doi: 10.1074/jbc.M008702200. J Biol Chem. 2001. PMID: 11042190 Free article.

10

Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.

Mukherjee A, Song E, Kihiko-Ehmann M, Goodman JP Jr, Pyrek JS, Estus S, Hersh LB. Mukherjee A, et al. Among authors: hersh lb. J Neurosci. 2000 Dec 1;20(23):8745-9. doi: 10.1523/JNEUROSCI.20-23-08745.2000. J Neurosci. 2000. PMID: 11102481 Free PMC article.

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