Koizumi M - Search Results

1

SNP genotyping by allele-specific PCR using ENA primers.

Koizumi M, Morita K, Takagi M, Yasumo H, Kasuya A. Koizumi M, et al. Nucleic Acids Symp Ser (Oxf). 2005;(49):47-8. doi: 10.1093/nass/49.1.47. Nucleic Acids Symp Ser (Oxf). 2005. PMID: 17150626

2

2'-O,4'-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug.

Morita K, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, Ishikawa T, Imanishi T, Koizumi M. Morita K, et al. Among authors: koizumi m. Bioorg Med Chem Lett. 2002 Jan 7;12(1):73-6. doi: 10.1016/s0960-894x(01)00683-7. Bioorg Med Chem Lett. 2002. PMID: 11738576

3

Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs.

Hamada M, Ohtsuka T, Kawaida R, Koizumi M, Morita K, Furukawa H, Imanishi T, Miyagishi M, Taira K. Hamada M, et al. Among authors: koizumi m. Antisense Nucleic Acid Drug Dev. 2002 Oct;12(5):301-9. doi: 10.1089/108729002761381285. Antisense Nucleic Acid Drug Dev. 2002. PMID: 12477280

4

Synthesis and properties of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) as effective antisense oligonucleotides.

Morita K, Takagi M, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, Ishikawa T, Imanishi T, Koizumi M. Morita K, et al. Among authors: koizumi m. Bioorg Med Chem. 2003 May 15;11(10):2211-26. doi: 10.1016/s0968-0896(03)00115-9. Bioorg Med Chem. 2003. PMID: 12713831

5

Triplex formation with 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) having C3'-endo conformation at physiological pH.

Koizumi M, Morita K, Daigo M, Tsutsumi S, Abe K, Obika S, Imanishi T. Koizumi M, et al. Nucleic Acids Res. 2003 Jun 15;31(12):3267-73. doi: 10.1093/nar/gkg416. Nucleic Acids Res. 2003. PMID: 12799454 Free PMC article.

6

Down-regulation of VEGF mRNA expression by 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) antisense oligonucleotides and investigation of non-target gene expression.

Morita K, Yamate K, Kurakata S, Abe K, Imanishi T, Koizumi M. Morita K, et al. Among authors: koizumi m. Nucleic Acids Res Suppl. 2002;(2):99-100. doi: 10.1093/nass/2.1.99. Nucleic Acids Res Suppl. 2002. PMID: 12903124

7

Design and synthesis of oatp subtype-specific antisense oligonucleotides having 2'-O,4'-C-ethylene-bridged nucleic acids (ENA).

Takagi M, Morita K, Nakai D, Nakagomi R, Tokui T, Koizumi M. Takagi M, et al. Among authors: koizumi m. Nucleic Acids Res Suppl. 2003;(3):83-4. doi: 10.1093/nass/3.1.83. Nucleic Acids Res Suppl. 2003. PMID: 14510391

8

2'-O,4'-C-ethylene-bridged nucleic acid (ENA) for effective antisense formation.

Morita K, Yamate K, Kurakata S, Watanabe K, Imanishi T, Koizumi M. Morita K, et al. Among authors: koizumi m. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1619-21. doi: 10.1081/NCN-120023082. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565480

9

Enhancement of the inhibitory activity of oatp antisense oligonucleotides by incorporation of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) without a loss of subtype selectivity.

Takagi M, Morita K, Nakai D, Nakagomi R, Tokui T, Koizumi M. Takagi M, et al. Among authors: koizumi m. Biochemistry. 2004 Apr 20;43(15):4501-10. doi: 10.1021/bi035847x. Biochemistry. 2004. PMID: 15078096

10

Chimeric RNA and 2'-O, 4'-C-ethylene-bridged nucleic acids have stronger activity than phosphorothioate oligodeoxynucleotides in induction of exon 19 skipping in dystrophin mRNA.

Yagi M, Takeshima Y, Surono A, Takagi M, Koizumi M, Matsuo M. Yagi M, et al. Among authors: koizumi m. Oligonucleotides. 2004 Spring;14(1):33-40. doi: 10.1089/154545704322988030. Oligonucleotides. 2004. PMID: 15104894

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