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Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. Niiranen K, et al. Among authors: uimari a. J Cell Mol Med. 2006 Oct-Dec;10(4):933-45. doi: 10.1111/j.1582-4934.2006.tb00536.x. J Cell Mol Med. 2006. PMID: 17125596 Free article.
Animal disease models generated by genetic engineering of polyamine metabolism.
Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A. Jänne J, et al. Among authors: uimari a. J Cell Mol Med. 2005 Oct-Dec;9(4):865-82. doi: 10.1111/j.1582-4934.2005.tb00385.x. J Cell Mol Med. 2005. PMID: 16364196 Free PMC article. Review.
Genetic manipulation of polyamine catabolism in rodents.
Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E, Järvinen A. Jänne J, et al. Among authors: uimari a. J Biochem. 2006 Feb;139(2):155-60. doi: 10.1093/jb/mvj035. J Biochem. 2006. PMID: 16452302 Review.
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J, Alhonen L. Vuohelainen S, et al. Among authors: uimari a. J Cell Mol Med. 2010 Jun;14(6B):1683-92. doi: 10.1111/j.1582-4934.2009.00808.x. Epub 2009 Jun 16. J Cell Mol Med. 2010. PMID: 19538475 Free PMC article.
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.
Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M. Koponen T, et al. Among authors: uimari a. Amino Acids. 2012 Feb;42(2-3):427-40. doi: 10.1007/s00726-011-1013-0. Epub 2011 Aug 4. Amino Acids. 2012. PMID: 21814795
36 results