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Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.
Tian X, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA. Tian X, et al. Among authors: mumin rn. J Med Chem. 2008 Oct 9;51(19):6055-66. doi: 10.1021/jm800525p. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771254