Mittelstadt SW - Search Results

1

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

Meyers KM, Kim N, Méndez-Andino JL, Hu XE, Mumin RN, Klopfenstein SR, Wos JA, Mitchell MC, Paris JL, Ackley DC, Holbert JK, Mittelstadt SW, Reizes O. Meyers KM, et al. Among authors: mittelstadt sw. Bioorg Med Chem Lett. 2007 Feb 1;17(3):814-8. doi: 10.1016/j.bmcl.2006.10.053. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107791

2

Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG.

Meyers KM, Méndez-Andino JL, Colson AO, Warshakoon NC, Wos JA, Mitchell MC, Hodge KM, Howard JM, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Reizes O, Hu XE. Meyers KM, et al. Among authors: mittelstadt sw. Bioorg Med Chem Lett. 2007 Feb 1;17(3):819-22. doi: 10.1016/j.bmcl.2006.10.052. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107796

3

The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists.

Méndez-Andino JL, Colson AO, Meyers KM, Mitchell MC, Hodge K, Howard JM, Kim N, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Suchanek P, Reizes O, Hu XE, Wos JA. Méndez-Andino JL, et al. Among authors: mittelstadt sw. Bioorg Med Chem. 2007 Mar 1;15(5):2092-105. doi: 10.1016/j.bmc.2006.12.028. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17236777

4

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Yeh VS, Beno DW, Brodjian S, Brune ME, Cullen SC, Dayton BD, Dhaon MK, Falls HD, Gao J, Grihalde N, Hajduk P, Hansen TM, Judd AS, King AJ, Klix RC, Larson KJ, Lau YY, Marsh KC, Mittelstadt SW, Plata D, Rozema MJ, Segreti JA, Stoner EJ, Voorbach MJ, Wang X, Xin X, Zhao G, Collins CA, Cox BF, Reilly RM, Kym PR, Souers AJ. Yeh VS, et al. Among authors: mittelstadt sw. J Med Chem. 2012 Feb 23;55(4):1751-7. doi: 10.1021/jm201524g. Epub 2012 Feb 10. J Med Chem. 2012. PMID: 22263872

5

Age-dependent effects on cisapride-induced QTc prolongation in the isolated guinea pig heart.

Mittelstadt SW, Adams NA, Spruell RD. Mittelstadt SW, et al. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):159-63. doi: 10.1016/j.vascn.2006.02.011. Epub 2006 Mar 3. J Pharmacol Toxicol Methods. 2006. PMID: 16624595

6

The Y2 receptor mediates increases in collateral-dependent blood flow in a model of peripheral arterial insufficiency.

Cruze CA, Su F, Limberg BJ, Deutsch AJ, Stoffolano PJ, Dai HJ, Buchanan DD, Yang HT, Terjung RL, Spruell RD, Mittelstadt SW, Rosenbaum JS. Cruze CA, et al. Among authors: mittelstadt sw. Peptides. 2007 Feb;28(2):269-80. doi: 10.1016/j.peptides.2006.09.026. Epub 2006 Dec 27. Peptides. 2007. PMID: 17194505

7

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG.

Mittelstadt SW, Hemenway CL, Craig MP, Hove JR. Mittelstadt SW, et al. J Pharmacol Toxicol Methods. 2008 Mar-Apr;57(2):100-5. doi: 10.1016/j.vascn.2007.10.004. Epub 2007 Dec 23. J Pharmacol Toxicol Methods. 2008. PMID: 18291682

8

Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.

George DM, Breinlinger EC, Friedman M, Zhang Y, Wang J, Argiriadi M, Bansal-Pakala P, Barth M, Duignan DB, Honore P, Lang Q, Mittelstadt S, Potin D, Rundell L, Edmunds JJ. George DM, et al. J Med Chem. 2015 Jan 8;58(1):222-36. doi: 10.1021/jm500669m. Epub 2014 Jul 7. J Med Chem. 2015. PMID: 25000588

9

Effects of fasting on evaluation of gastrointestinal transit with charcoal meal.

Mittelstadt SW, Hemenway CL, Spruell RD. Mittelstadt SW, et al. J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):154-8. doi: 10.1016/j.vascn.2005.04.017. J Pharmacol Toxicol Methods. 2005. PMID: 15963735

10

Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster.

King AJ, Segreti JA, Larson KJ, Souers AJ, Kym PR, Reilly RM, Zhao G, Mittelstadt SW, Cox BF. King AJ, et al. Among authors: mittelstadt sw. J Pharmacol Exp Ther. 2009 Aug;330(2):526-31. doi: 10.1124/jpet.109.154047. Epub 2009 May 28. J Pharmacol Exp Ther. 2009. PMID: 19478132

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