Martin J - Search Results

1

A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.

Mayer A, Francis RJ, Sharma SK, Tolner B, Springer CJ, Martin J, Boxer GM, Bell J, Green AJ, Hartley JA, Cruickshank C, Wren J, Chester KA, Begent RH. Mayer A, et al. Among authors: martin j. Clin Cancer Res. 2006 Nov 1;12(21):6509-16. doi: 10.1158/1078-0432.CCR-06-0769. Clin Cancer Res. 2006. PMID: 17085666 Clinical Trial.

2

Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.

Napier MP, Sharma SK, Springer CJ, Bagshawe KD, Green AJ, Martin J, Stribbling SM, Cushen N, O'Malley D, Begent RH. Napier MP, et al. Among authors: martin j. Clin Cancer Res. 2000 Mar;6(3):765-72. Clin Cancer Res. 2000. PMID: 10741695 Clinical Trial.

3

A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours.

Francis RJ, Sharma SK, Springer C, Green AJ, Hope-Stone LD, Sena L, Martin J, Adamson KL, Robbins A, Gumbrell L, O'Malley D, Tsiompanou E, Shahbakhti H, Webley S, Hochhauser D, Hilson AJ, Blakey D, Begent RH. Francis RJ, et al. Among authors: martin j. Br J Cancer. 2002 Sep 9;87(6):600-7. doi: 10.1038/sj.bjc.6600517. Br J Cancer. 2002. PMID: 12237768 Free PMC article. Clinical Trial.

4

Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.

Friedlos F, Lehouritis P, Ogilvie L, Hedley D, Davies L, Bermudes D, King I, Martin J, Marais R, Springer CJ. Friedlos F, et al. Among authors: martin j. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. doi: 10.1158/1078-0432.CCR-07-4800. Clin Cancer Res. 2008. PMID: 18594008

5

Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.

Schepelmann S, Hallenbeck P, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Hay C, Hawkins LK, Marais R, Springer CJ. Schepelmann S, et al. Among authors: martin j. Cancer Res. 2005 Jun 15;65(12):5003-8. doi: 10.1158/0008-5472.CAN-05-0393. Cancer Res. 2005. PMID: 15958540

6

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ. Schepelmann S, et al. Among authors: martin j. Cancer Res. 2007 May 15;67(10):4949-55. doi: 10.1158/0008-5472.CAN-07-0297. Cancer Res. 2007. PMID: 17510425 Free article.

7

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.

Marais R, Spooner RA, Light Y, Martin J, Springer CJ. Marais R, et al. Among authors: martin j. Cancer Res. 1996 Oct 15;56(20):4735-42. Cancer Res. 1996. PMID: 8840992

8

Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial.

Martin J, Stribbling SM, Poon GK, Begent RH, Napier M, Sharma SK, Springer CJ. Martin J, et al. Cancer Chemother Pharmacol. 1997;40(3):189-201. doi: 10.1007/s002800050646. Cancer Chemother Pharmacol. 1997. PMID: 9219501 Clinical Trial.

9

Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft.

Stribbling SM, Martin J, Pedley RB, Boden JA, Sharma SK, Springer CJ. Stribbling SM, et al. Among authors: martin j. Cancer Chemother Pharmacol. 1997;40(4):277-84. doi: 10.1007/s002800050659. Cancer Chemother Pharmacol. 1997. PMID: 9225945

10

Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.

Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ. Davies LC, et al. Among authors: martin j. J Med Chem. 2005 Aug 11;48(16):5321-8. doi: 10.1021/jm0502182. J Med Chem. 2005. PMID: 16078849

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