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A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.
Mayer A, Francis RJ, Sharma SK, Tolner B, Springer CJ, Martin J, Boxer GM, Bell J, Green AJ, Hartley JA, Cruickshank C, Wren J, Chester KA, Begent RH. Mayer A, et al. Among authors: green aj. Clin Cancer Res. 2006 Nov 1;12(21):6509-16. doi: 10.1158/1078-0432.CCR-06-0769. Clin Cancer Res. 2006. PMID: 17085666 Clinical Trial.
A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomas.
Meyer T, Gaya AM, Dancey G, Stratford MR, Othman S, Sharma SK, Wellsted D, Taylor NJ, Stirling JJ, Poupard L, Folkes LK, Chan PS, Pedley RB, Chester KA, Owen K, Violet JA, Malaroda A, Green AJ, Buscombe J, Padhani AR, Rustin GJ, Begent RH. Meyer T, et al. Among authors: green aj. Clin Cancer Res. 2009 Jul 1;15(13):4484-92. doi: 10.1158/1078-0432.CCR-09-0035. Epub 2009 Jun 23. Clin Cancer Res. 2009. PMID: 19549771 Free article. Clinical Trial.
A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours.
Francis RJ, Sharma SK, Springer C, Green AJ, Hope-Stone LD, Sena L, Martin J, Adamson KL, Robbins A, Gumbrell L, O'Malley D, Tsiompanou E, Shahbakhti H, Webley S, Hochhauser D, Hilson AJ, Blakey D, Begent RH. Francis RJ, et al. Among authors: green aj. Br J Cancer. 2002 Sep 9;87(6):600-7. doi: 10.1038/sj.bjc.6600517. Br J Cancer. 2002. PMID: 12237768 Free PMC article. Clinical Trial.
Radiolabelling of glycosylated MFE-23::CPG2 fusion protein (MFECP1) with 99mTc for quantitation of tumour antibody-enzyme localisation in antibody-directed enzyme pro-drug therapy (ADEPT).
Francis RJ, Mather SJ, Chester K, Sharma SK, Bhatia J, Pedley RB, Waibel R, Green AJ, Begent RH. Francis RJ, et al. Among authors: green aj. Eur J Nucl Med Mol Imaging. 2004 Aug;31(8):1090-6. doi: 10.1007/s00259-004-1474-4. Epub 2004 Mar 17. Eur J Nucl Med Mol Imaging. 2004. PMID: 15029458
Engineering antibodies for clinical applications in cancer.
Chester K, Pedley B, Tolner B, Violet J, Mayer A, Sharma S, Boxer G, Green A, Nagl S, Begent R. Chester K, et al. Tumour Biol. 2004 Jan-Apr;25(1-2):91-8. doi: 10.1159/000077727. Tumour Biol. 2004. PMID: 15192316 Review.
A Phase I Clinical Trial of CHT-25 a 131I-Labeled Chimeric Anti-CD25 Antibody Showing Efficacy in Patients with Refractory Lymphoma.
Dancey G, Violet J, Malaroda A, Green AJ, Sharma SK, Francis R, Othman S, Parker S, Buscombe J, Griffin N, Chan PS, Malhotra A, Woodward N, Ramsay A, Ross P, Lister TA, Amlot P, Begent R, McNamara C. Dancey G, et al. Among authors: green aj. Clin Cancer Res. 2009 Dec 15;15(24):7701-7710. doi: 10.1158/1078-0432.CCR-09-1421. Clin Cancer Res. 2009. PMID: 20008855
521 results