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Page 1
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Giblin GM, Bit RA, Brown SH, Chaignot HM, Chowdhury A, Chessell IP, Clayton NM, Coleman T, Hall A, Hammond B, Hurst DN, Michel AD, Naylor A, Novelli R, Scoccitti T, Spalding D, Tang SP, Wilson AW, Wilson R. Giblin GM, et al. Among authors: novelli r. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. doi: 10.1016/j.bmcl.2006.10.041. Epub 2006 Oct 20. Bioorg Med Chem Lett. 2007. PMID: 17084082
Discovery of novel biaryl heterocyclic EP1 receptor antagonists.
Hall A, Bit RA, Brown SH, Chaignot HM, Chessell IP, Coleman T, Giblin GM, Hurst DN, Kilford IR, Lewell XQ, Michel AD, Mohamed S, Naylor A, Novelli R, Skinner L, Spalding DJ, Tang SP, Wilson RJ. Hall A, et al. Among authors: novelli r. Bioorg Med Chem Lett. 2006 May 15;16(10):2666-71. doi: 10.1016/j.bmcl.2006.02.014. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503138
Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.
Hall A, Atkinson S, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Gleave RJ, Hammond B, Healy MP, Johnson MR, Michel AD, Naylor A, Novelli R, Spalding DJ, Tang SP. Hall A, et al. Among authors: novelli r. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3657-62. doi: 10.1016/j.bmcl.2006.04.073. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16697196
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives.
Hall A, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Hammond B, Healy MP, Johnson MR, Metcalf A, Michel AD, Naylor A, Novelli R, Spalding DJ, Sweeting J. Hall A, et al. Among authors: novelli r. Bioorg Med Chem Lett. 2007 Feb 1;17(3):732-5. doi: 10.1016/j.bmcl.2006.10.078. Epub 2006 Oct 28. Bioorg Med Chem Lett. 2007. PMID: 17098427
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.
Hall A, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Hammond B, Healy MP, Johnson MR, Metcalf A, Michel AD, Naylor A, Novelli R, Spalding DJ, Sweeting J, Winyard L. Hall A, et al. Among authors: novelli r. Bioorg Med Chem Lett. 2007 Feb 15;17(4):916-20. doi: 10.1016/j.bmcl.2006.11.059. Epub 2006 Nov 22. Bioorg Med Chem Lett. 2007. PMID: 17175160
Early transtympanic administration of rhBDNF exerts a multifaceted neuroprotective effect against cisplatin-induced hearing loss.
Pisani A, Rolesi R, Mohamed-Hizam V, Montuoro R, Paludetti G, Giorgio C, Cocchiaro P, Brandolini L, Detta N, Sirico A, Amendola PG, Novelli R, Aramini A, Allegretti M, Paciello F, Grassi C, Fetoni AR. Pisani A, et al. Among authors: novelli r. Br J Pharmacol. 2025 Feb;182(3):546-563. doi: 10.1111/bph.17359. Epub 2024 Oct 10. Br J Pharmacol. 2025. PMID: 39390645
Nutraceuticals in Psychiatric Disorders: A Systematic Review.
Bozzatello P, Novelli R, Montemagni C, Rocca P, Bellino S. Bozzatello P, et al. Among authors: novelli r. Int J Mol Sci. 2024 Apr 28;25(9):4824. doi: 10.3390/ijms25094824. Int J Mol Sci. 2024. PMID: 38732043 Free PMC article.
Combination Drug Therapy for the Management of Chronic Neuropathic Pain.
Boccella S, De Filippis L, Giorgio C, Brandolini L, Jones M, Novelli R, Amorizzo E, Leoni MLG, Terranova G, Maione S, Luongo L, Leone M, Allegretti M, Minnella EM, Aramini A. Boccella S, et al. Among authors: novelli r. Biomolecules. 2023 Dec 16;13(12):1802. doi: 10.3390/biom13121802. Biomolecules. 2023. PMID: 38136672 Free PMC article. Review.
The therapeutic potential of an allosteric non-competitive CXCR1/2 antagonist for diabetic nephropathy.
Grasselli C, Bombelli S, D'Esposito V, Di Tolla MF, L'Imperio V, Rocchio F, Miscione MS, Formisano P, Pagni F, Novelli R, Ruffini PA, Aramini A, Allegretti M, Perego R, De Filippis L. Grasselli C, et al. Among authors: novelli r. Diabetes Metab Res Rev. 2023 Oct;39(7):e3694. doi: 10.1002/dmrr.3694. Epub 2023 Jul 20. Diabetes Metab Res Rev. 2023. PMID: 37470287 Free article.
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action.
Iaconis D, Caccuri F, Manelfi C, Talarico C, Bugatti A, Filippini F, Zani A, Novelli R, Kuzikov M, Ellinger B, Gribbon P, Riecken K, Esposito F, Corona A, Tramontano E, Beccari AR, Caruso A, Allegretti M. Iaconis D, et al. Among authors: novelli r. Viruses. 2023 May 9;15(5):1128. doi: 10.3390/v15051128. Viruses. 2023. PMID: 37243214 Free PMC article.
52 results