Takayama H - Search Results

1

Biological activities of 2alpha-substituted analogues of 1alpha,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation.

Takahashi E, Nakagawa K, Suhara Y, Kittaka A, Nihei K, Konno K, Takayama H, Ozono K, Okano T. Takahashi E, et al. Among authors: takayama h. Biol Pharm Bull. 2006 Nov;29(11):2246-50. doi: 10.1248/bpb.29.2246. Biol Pharm Bull. 2006. PMID: 17077522 Free article.

2

Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity.

Suhara Y, Kittaka A, Kishimoto S, Calverley MJ, Fujishima T, Saito N, Sugiura T, Waku K, Takayama H. Suhara Y, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3255-8. doi: 10.1016/s0960-894x(02)00722-9. Bioorg Med Chem Lett. 2002. PMID: 12392726

3

2 alpha-(3-hydroxypropyl)- and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets.

Kittaka A, Kurihara M, Peleg S, Suhara Y, Takayama H. Kittaka A, et al. Among authors: takayama h. Chem Pharm Bull (Tokyo). 2003 Mar;51(3):357-8. doi: 10.1248/cpb.51.357. Chem Pharm Bull (Tokyo). 2003. PMID: 12612432 Free article.

4

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs.

Takayama H, Kittaka A, Fujishima T, Suhara Y. Takayama H, et al. Recent Results Cancer Res. 2003;164:289-317. doi: 10.1007/978-3-642-55580-0_21. Recent Results Cancer Res. 2003. PMID: 12899530 Review.

5

Efficient synthesis of 2-modified 1alpha,25-dihydroxy-19-norvitamin D3 with Julia olefination: high potency in induction of differentiation on HL-60 cells.

Ono K, Yoshida A, Saito N, Fujishima T, Honzawa S, Suhara Y, Kishimoto S, Sugiura T, Waku K, Takayama H, Kittaka A. Ono K, et al. Among authors: takayama h. J Org Chem. 2003 Sep 19;68(19):7407-15. doi: 10.1021/jo034787y. J Org Chem. 2003. PMID: 12968893

6

Concise synthesis and biological activities of 2alpha-alkyl- and 2alpha-(omega-hydroxyalkyl)-20-epi-1alpha,25-dihydroxyvitamin D3.

Honzawa S, Suhara Y, Nihei K, Saito N, Kishimoto S, Fujishima T, Kurihara M, Sugiura T, Waku K, Takayama H, Kittaka A. Honzawa S, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3503-6. doi: 10.1016/s0960-894x(03)00739-x. Bioorg Med Chem Lett. 2003. PMID: 14505658

7

Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D3 Analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity.

Saito N, Suhara Y, Kurihara M, Fujishima T, Honzawa S, Takayanagi H, Kozono T, Matsumoto M, Ohmori M, Miyata N, Takayama H, Kittaka A. Saito N, et al. Among authors: takayama h. J Org Chem. 2004 Oct 29;69(22):7463-71. doi: 10.1021/jo0491051. J Org Chem. 2004. PMID: 15497970

8

Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells.

Nakagawa K, Kurobe M, Ozono K, Konno K, Fujishima T, Takayama H, Okano T. Nakagawa K, et al. Among authors: takayama h. Biochem Pharmacol. 2000 Mar 15;59(6):691-702. doi: 10.1016/s0006-2952(99)00357-3. Biochem Pharmacol. 2000. PMID: 10677586

9

Syntheses and biological evaluation of novel 2alpha-substituted 1alpha,25-dihydroxyvitamin D3 analogues.

Suhara Y, Nihei KI, Tanigawa H, Fujishima T, Konno K, Nakagawa K, Okano T, Takayama H. Suhara Y, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2000 May 15;10(10):1129-32. doi: 10.1016/s0960-894x(00)00189-x. Bioorg Med Chem Lett. 2000. PMID: 10843234

10

Efficient synthesis and biological evaluation of all A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 and its 20-epimer.

Fujishima T, Konno K, Nakagawa K, Kurobe M, Okano T, Takayama H. Fujishima T, et al. Among authors: takayama h. Bioorg Med Chem. 2000 Jan;8(1):123-34. doi: 10.1016/s0968-0896(99)00262-x. Bioorg Med Chem. 2000. PMID: 10968271

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