LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia.
Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K, Zeidler C, Lehmann U, Eder M, Baum C, Grosschedl R, Stanulla M, Scherr M, Welte K.
Skokowa J, et al. Among authors: eder m.
Nat Med. 2006 Oct;12(10):1191-7. doi: 10.1038/nm1474. Epub 2006 Sep 24.
Nat Med. 2006.
PMID: 17063141