Lokey RS - Search Results

1

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides.

Rezai T, Bock JE, Zhou MV, Kalyanaraman C, Lokey RS, Jacobson MP. Rezai T, et al. Among authors: lokey rs. J Am Chem Soc. 2006 Nov 1;128(43):14073-80. doi: 10.1021/ja063076p. J Am Chem Soc. 2006. PMID: 17061890

2

Geometric diversity through permutation of backbone configuration in cyclic peptide libraries.

Perlman ZE, Bock JE, Peterson JR, Lokey RS. Perlman ZE, et al. Among authors: lokey rs. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5329-34. doi: 10.1016/j.bmcl.2005.07.089. Epub 2005 Oct 6. Bioorg Med Chem Lett. 2005. PMID: 16213707

3

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

Rezai T, Yu B, Millhauser GL, Jacobson MP, Lokey RS. Rezai T, et al. Among authors: lokey rs. J Am Chem Soc. 2006 Mar 1;128(8):2510-1. doi: 10.1021/ja0563455. J Am Chem Soc. 2006. PMID: 16492015

4

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Gassner NC, et al. Among authors: lokey rs. J Nat Prod. 2007 Mar;70(3):383-90. doi: 10.1021/np060555t. Epub 2007 Feb 10. J Nat Prod. 2007. PMID: 17291044 Free PMC article.

5

Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides.

Turner RA, Oliver AG, Lokey RS. Turner RA, et al. Among authors: lokey rs. Org Lett. 2007 Nov 22;9(24):5011-4. doi: 10.1021/ol702228u. Epub 2007 Oct 23. Org Lett. 2007. PMID: 17956112

6

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.

White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, Jacobson MP, Lokey RS. White TR, et al. Among authors: lokey rs. Nat Chem Biol. 2011 Sep 25;7(11):810-7. doi: 10.1038/nchembio.664. Nat Chem Biol. 2011. PMID: 21946276 Free PMC article.

7

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

Rand AC, Leung SS, Eng H, Rotter CJ, Sharma R, Kalgutkar AS, Zhang Y, Varma MV, Farley KA, Khunte B, Limberakis C, Price DA, Liras S, Mathiowetz AM, Jacobson MP, Lokey RS. Rand AC, et al. Among authors: lokey rs. Medchemcomm. 2012 Oct;3(10):1282-1289. doi: 10.1039/C2MD20203D. Medchemcomm. 2012. PMID: 23133740 Free PMC article.

8

Designing molecules to cross biological membranes.

Lokey RS, Liras J, Liras S, Jacobson MP. Lokey RS, et al. Curr Top Med Chem. 2013;13(7):775. doi: 10.2174/1568026611313070001. Curr Top Med Chem. 2013. PMID: 23578022 No abstract available.

9

Form and function in cyclic peptide natural products: a pharmacokinetic perspective.

Bockus AT, McEwen CM, Lokey RS. Bockus AT, et al. Among authors: lokey rs. Curr Top Med Chem. 2013;13(7):821-36. doi: 10.2174/1568026611313070005. Curr Top Med Chem. 2013. PMID: 23578026 Review.

10

Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.

Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Hewitt WM, et al. Among authors: lokey rs. J Am Chem Soc. 2015 Jan 21;137(2):715-21. doi: 10.1021/ja508766b. Epub 2015 Jan 8. J Am Chem Soc. 2015. PMID: 25517352

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