Lyu PC - Search Results

1

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Mahindroo N, Peng YH, Lin CH, Tan UK, Prakash E, Lien TW, Lu IL, Lee HJ, Hsu JT, Chen X, Liao CC, Lyu PC, Chao YS, Wu SY, Hsieh HP. Mahindroo N, et al. Among authors: lyu pc. J Med Chem. 2006 Oct 19;49(21):6421-4. doi: 10.1021/jm060663c. J Med Chem. 2006. PMID: 17034149

2

Conantokin-T selectively antagonizes N-methyl-D-aspartate-evoked responses in rat hippocampal slice.

Huang CC, Lyu PC, Lin CH, Hsu KS. Huang CC, et al. Among authors: lyu pc. Toxicon. 1997 Mar;35(3):355-63. doi: 10.1016/s0041-0101(96)00171-7. Toxicon. 1997. PMID: 9080592

3

Role of modified glutamic acid in the helical structure of conantokin-T.

Lin CH, Chen CS, Hsu KS, King DS, Lyu PC. Lin CH, et al. Among authors: lyu pc. FEBS Lett. 1997 Apr 28;407(2):243-8. doi: 10.1016/s0014-5793(97)00354-2. FEBS Lett. 1997. PMID: 9166908 Free article.

4

Calcium binding mode of gamma-carboxyglutamic acids in conantokins.

Lin CH, Chan FC, Hwang JK, Lyu PC. Lin CH, et al. Among authors: lyu pc. Protein Eng. 1999 Jul;12(7):589-95. doi: 10.1093/protein/12.7.589. Protein Eng. 1999. PMID: 10436085

5

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Mahindroo N, Wang CC, Liao CC, Huang CF, Lu IL, Lien TW, Peng YH, Huang WJ, Lin YT, Hsu MC, Lin CH, Tsai CH, Hsu JT, Chen X, Lyu PC, Chao YS, Wu SY, Hsieh HP. Mahindroo N, et al. Among authors: lyu pc. J Med Chem. 2006 Feb 9;49(3):1212-6. doi: 10.1021/jm0510373. J Med Chem. 2006. PMID: 16451087

6

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Chiang YK, Kuo CC, Wu YS, Chen CT, Coumar MS, Wu JS, Hsieh HP, Chang CY, Jseng HY, Wu MH, Leou JS, Song JS, Chang JY, Lyu PC, Chao YS, Wu SY. Chiang YK, et al. Among authors: lyu pc. J Med Chem. 2009 Jul 23;52(14):4221-33. doi: 10.1021/jm801649y. J Med Chem. 2009. PMID: 19507860

7

Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.

Chen JC, Uang BJ, Lyu PC, Chang JY, Liu KJ, Kuo CC, Hsieh HP, Wang HC, Cheng CS, Chang YH, Chang MD, Chang WS, Lin CC. Chen JC, et al. Among authors: lyu pc. J Med Chem. 2010 Jun 10;53(11):4545-9. doi: 10.1021/jm100089e. J Med Chem. 2010. PMID: 20481438

8

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists.

Peng YH, Coumar MS, Leou JS, Wu JS, Shiao HY, Lin CH, Lin WH, Lien TW, Chen X, Hsu JT, Chao YS, Huang CF, Lyu PC, Hsieh HP, Wu SY. Peng YH, et al. Among authors: lyu pc. ChemMedChem. 2010 Oct 4;5(10):1707-16. doi: 10.1002/cmdc.201000194. ChemMedChem. 2010. PMID: 20734309

9

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.

Peng YH, Shiao HY, Tu CH, Liu PM, Hsu JT, Amancha PK, Wu JS, Coumar MS, Chen CH, Wang SY, Lin WH, Sun HY, Chao YS, Lyu PC, Hsieh HP, Wu SY. Peng YH, et al. Among authors: lyu pc. J Med Chem. 2013 May 23;56(10):3889-903. doi: 10.1021/jm400072p. Epub 2013 May 10. J Med Chem. 2013. PMID: 23611691

10

Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).

Tu CH, Lin WH, Peng YH, Hsu T, Wu JS, Chang CY, Lu CT, Lyu PC, Shih C, Jiaang WT, Wu SY. Tu CH, et al. Among authors: lyu pc. J Med Chem. 2016 Apr 28;59(8):3906-19. doi: 10.1021/acs.jmedchem.6b00106. Epub 2016 Apr 12. J Med Chem. 2016. PMID: 27031565

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