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Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.
Lupu DS, Orozco LD, Wang Y, Cullen JM, Pellegrini M, Zeisel SH. Lupu DS, et al. Among authors: wang y. FASEB J. 2017 May;31(5):2090-2103. doi: 10.1096/fj.201601169R. Epub 2017 Feb 8. FASEB J. 2017. PMID: 28179424 Free PMC article.
At all time points, we found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 (proteinase-activated receptor-3), 2 genes that were also silenced and underexpressed, respectively.-Lupu, D. S., Orozco, L. D., Wang, Y …
At all time points, we found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 (proteina …
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